Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7398418 | 0.85 | TDP1 (0.53) | TDP1KEAP1FFAR1ALDH1A1LMNA | |
| SCHEMBL7299043 | 0.83 | MAPT (0.53) | TDP1KEAP1FFAR1ALDH1A1HDAC2 | |
| SCHEMBL3291001 | 0.83 | KEAP1 (0.52) | TDP1KEAP1FFAR1ALDH1A1LMNA | |
| SCHEMBL9116026 | 0.83 | ALDH1A1 (0.46) | ALDH1A1LMNAHDAC8HDAC6MAPK1 | |
| SCHEMBL5704682 | 0.82 | TDP1 (0.54) | TDP1KEAP1FFAR1ALDH1A1LMNA | |
| SCHEMBL28007941 | 0.80 | TDP1 (0.51) | TDP1KEAP1FFAR1ALDH1A1LMNA | |
| SCHEMBL1093411 | 0.80 | TDP1 (0.47) | TDP1KEAP1FFAR1ALDH1A1HDAC2 | |
| SCHEMBL3997663 | 0.79 | ALDH1A1 (0.53) | TDP1KEAP1FFAR1ALDH1A1LMNA | |
| SCHEMBL27488874 | 0.79 | TDP1 (0.75) | TDP1KEAP1FFAR1ALDH1A1LMNA | |
| SCHEMBL2289190 | 0.78 | TDP1 (0.46) | TDP1KEAP1FFAR1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007111994-A2 | COMPOUNDS AND METHODS FOR TREATMENT OF DISORDERS ASSOCIATED WITH ER STRESS | SYNDEXA PHARMACEUTICALS CORPORATION (US) | 2007-10-04 | — | — | WO | disclosed |