Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | XBP1 | P17861 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.31 |
| ▸ | GLP1R | P43220 | 3/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.31 |
| ▸ | BPTF | Q12830 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4444099 | 0.81 | GLP1R (0.43) | LMNASMN1; SMN2ALDH1A1MAPTNPC1 | |
| SCHEMBL63292 | 0.80 | LMNA (0.50) | LMNASMN1; SMN2ALDH1A1MAPTMEN1 | |
| SCHEMBL13703901 | 0.76 | LMNA (0.42) | LMNASMN1; SMN2ALDH1A1MAPTMEN1 | |
| SCHEMBL11585339 | 0.73 | LMNA (0.44) | LMNASMN1; SMN2ALDH1A1MAPTMEN1 | |
| SCHEMBL6296316 | 0.73 | LMNA (0.44) | LMNASMN1; SMN2ALDH1A1MAPTKMT2A | |
| SCHEMBL11107779 | 0.72 | LMNA (0.47) | LMNASMN1; SMN2ALDH1A1MAPTMEN1 | |
| SCHEMBL8597269 | 0.72 | LMNA (0.42) | LMNASMN1; SMN2ALDH1A1MAPTMEN1 | |
| SCHEMBL8666206 | 0.70 | SMN1; SMN2 (0.78) | LMNASMN1; SMN2ALDH1A1MAPTMEN1 | |
| SCHEMBL9432390 | 0.70 | SMN1; SMN2 (0.50) | LMNASMN1; SMN2ALDH1A1MAPTMEN1 | |
| SCHEMBL11512309 | 0.70 | LMNA (0.38) | LMNASMN1; SMN2ALDH1A1MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070249031-A1 | Aminopyrimidines useful as kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2007-10-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070249031-A1 | Aminopyrimidines useful as kinase inhibitors | ABL1, PRKDC, MAP3K5 | LMNA 3688/4885SMN1; SMN2 2138/4885ALDH1A1 2217/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.