Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13906071 | 0.88 | HSP90AA1 (0.42) | MEN1KMT2AALDH1A1HPGDHSP90AA1 | |
| SCHEMBL12561619 | 0.83 | TRPC3 (0.43) | TSHRMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL12376652 | 0.78 | LMNA (0.42) | MEN1KMT2AALDH1A1HSP90AA1HSP90AB1 | |
| SCHEMBL29812169 | 0.74 | TYK2 (0.41) | MEN1KMT2AHSP90AA1HSP90AB1LMNA | |
| SCHEMBL24571817 | 0.69 | ALDH1A1 (0.76) | MEN1KMT2AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL9004445 | 0.68 | MET (0.53) | MEN1KMT2ACYP3A4RIPK3 | |
| SCHEMBL18896227 | 0.65 | ALDH1A1 (0.52) | MEN1KMT2AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL18896304 | 0.65 | CTSL (0.55) | MEN1KMT2AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL12376646 | 0.65 | RIPK1 (0.44) | MEN1KMT2AALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL14109842 | 0.65 | TDP1 (0.43) | MEN1KMT2AALDH1A1HPGDHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007103308-A2 | HETEROBICYCLIC PYRAZOLE COMPOUNDS AND METHODS OF USE | ARRAY BIOPHARMA INC. (US) | 2007-09-13 | — | — | WO | disclosed |