SCHEMBL14415974

SCHEMBL14415974

c1ccc(CNCCc2cnc[nH]2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
HRH4 Q9H3N8 4/20 1.00
TAAR1 Q96RJ0 2/20 0.65
HRH3 Q9Y5N1 5/20 0.62
MEN1 O00255 1/20 0.59
KMT2A Q03164 1/20 0.59
HRH2 P25021 1/20 0.56
HDAC1 Q13547 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24732099 0.85 HRH4 (0.73) HRH4TAAR1HRH3HRH2
SCHEMBL224745 0.79 TAAR1 (1.00) HRH4TAAR1HRH3
SCHEMBL29396933 0.79 HRH4 (0.65) HRH4HRH3MEN1KMT2AHDAC1
SCHEMBL4897840 0.78 TAAR1 (0.67) HRH4TAAR1HRH3
SCHEMBL2536900 0.76 HRH3 (0.93) HRH4TAAR1HRH3HRH2
SCHEMBL13073926 0.74 HRH3 (0.77) HRH4HRH3MEN1KMT2A
SCHEMBL3934417 0.74 HRH3 (0.61) HRH4HRH3MEN1KMT2AHRH2
SCHEMBL1034848 0.73 HRH3 (1.00) HRH4TAAR1HRH3
SCHEMBL22894793 0.73 HRH4 (0.57) HRH4HRH3MEN1KMT2A
SCHEMBL25634469 0.73 HRH4 (0.57) HRH4HRH3MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12247027-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2025-03-11 US disclosed
US-20240116930-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2024-04-11 US disclosed
US-11820770-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2023-11-21 US disclosed
US-20220213095-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2022-07-07 US disclosed
US-11225478-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2022-01-18 US disclosed
US-11186572-B2 Bacterial glutaminyl cyclases and inhibitors thereof for use in the treatment of periodontitis FRAUNHOFER-GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG E.V. (DE) 2021-11-30 US disclosed
CN-110003200-B P2X7 modulators 詹森药业有限公司 2021-11-26 CN disclosed
EP-3548613-B1 BACTERIAL GLUTAMINYL CYCLASE INHIBITORS AND USE THEREOF IN THE TREATMENT OF PERIODONTITIS FRAUNHOFER GES FORSCHUNG (DE) 2021-01-27 EP disclosed
US-20200325138-A1 P2X7 Modulators JANSSEN PHARMACEUTICA NV (BE) 2020-10-15 US disclosed
US-10703749-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2020-07-07 US disclosed
EP-2970267-B1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2017-05-24 EP disclosed
US-20160376271-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV 2016-12-29 US disclosed
US-9464084-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2016-10-11 US disclosed
US-20160039809-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2016-02-11 US disclosed
EP-2970267-A1 P2X7 MODULATORS Janssen Pharmaceutica, N.V. (BE) 2016-01-20 EP disclosed
US-20150322062-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2015-11-12 US disclosed
US-9066946-B2 P2X7 modulators JANSSEN PHARMACEUTICA NV (BE) 2015-06-30 US disclosed
WO-2014152604-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2014-09-25 WO disclosed
US-20140275015-A1 P2X7 MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2014-09-18 US disclosed
US-20070213340-A1 Farnesyl protein transferase inhibitors SCHERING CORPORATION 2007-09-13 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200325138-A1 P2X7 Modulators P2RX2, P2RX7, P2RY2 HRH4 1162/4885TAAR1 894/4885HRH3 1273/4885
US-12247027-B2 P2X7 modulators P2RX2, P2RX7, P2RY2 HRH4 1162/4885TAAR1 894/4885HRH3 1273/4885
US-20160376271-A1 P2X7 MODULATORS P2RX2, P2RX7, P2RY2 HRH4 1162/4885TAAR1 894/4885HRH3 1273/4885
US-11186572-B2 Bacterial glutaminyl cyclases and inhibitors thereof for use in the treatment of periodontitis GMPS, QPCT, GLS HRH4 2543/4885TAAR1 4111/4885HRH3 2365/4885
US-11225478-B2 P2X7 modulators P2RX2, P2RX7, P2RY2 HRH4 1162/4885TAAR1 894/4885HRH3 1273/4885
US-20070213340-A1 Farnesyl protein transferase inhibitors FNTB, FNTA, FDPS HRH4 2441/4885TAAR1 4708/4885HRH3 3867/4885
US-20160039809-A1 P2X7 MODULATORS P2RX2, P2RX7, P2RX5 HRH4 1082/4885TAAR1 770/4885HRH3 1157/4885
US-20150322062-A1 P2X7 MODULATORS P2RX2, P2RX7, P2RY2 HRH4 1162/4885TAAR1 894/4885HRH3 1273/4885
US-11820770-B2 P2X7 modulators P2RX2, P2RX7, P2RY2 HRH4 1162/4885TAAR1 894/4885HRH3 1273/4885
US-20220213095-A1 P2X7 MODULATORS P2RX2, P2RX7, P2RY2 HRH4 1162/4885TAAR1 894/4885HRH3 1273/4885
US-20240116930-A1 P2X7 MODULATORS P2RX2, P2RX7, P2RY2 HRH4 1162/4885TAAR1 894/4885HRH3 1273/4885
US-10703749-B2 P2X7 modulators P2RX2, P2RX7, P2RY2 HRH4 1162/4885TAAR1 894/4885HRH3 1273/4885
US-20140275015-A1 P2X7 MODULATORS P2RX2, P2RX7, P2RY2 HRH4 1162/4885TAAR1 894/4885HRH3 1273/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.