Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | SPR | P35270 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14417819 | 0.83 | KDM1A (0.36) | NAMPTALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL14417859 | 0.82 | VNN1 (0.36) | NAMPTALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL14417828 | 0.80 | NAMPT (0.42) | NAMPTALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL13360768 | 0.80 | ALDH1A1 (0.52) | NAMPTALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL4438715 | 0.78 | ALDH1A1 (0.53) | NAMPTALDH1A1LMNASPR | |
| SCHEMBL8903167 | 0.78 | NAMPT (0.37) | NAMPTALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL13438125 | 0.78 | CPN1 (0.39) | NAMPTALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL14417849 | 0.77 | ALDH1A1 (0.40) | NAMPTALDH1A1MEN1KMT2ATDP1 | |
| SCHEMBL14417858 | 0.75 | NAMPT (0.39) | NAMPTALDH1A1USP2CYP3A4EPHX2 | |
| SCHEMBL25840967 | 0.75 | KDM4E (0.40) | NAMPTALDH1A1MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7268150-B2 | 2-cyano-4-fluoropyrrolidine derivative or its salt | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2007-09-11 | — | — | US | disclosed |
| US-7268150-B2 | 2-cyano-4-fluoropyrrolidine derivative or its salt | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2007-09-11 | — | — | US | disclosed |