SCHEMBL14423366

SCHEMBL14423366

C=CC/C(C)=C/[Si](C)(C)c1ccc(C)cc1

nearest known ligand 0.35

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
MMP9 P14780 1/20 0.35
NR1H2 P55055 2/20 0.33
NR1H3 Q13133 2/20 0.33
MMP2 P08253 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14423360 0.85 MMP9 (0.34) MMP9NR1H2NR1H3
SCHEMBL3378809 0.71 NR1H2 (0.52) MMP9NR1H2NR1H3MMP2
SCHEMBL3784329 0.68 ALDH1A1 (0.38)
SCHEMBL10941257 0.66 NR1H2 (0.56) MMP9NR1H2NR1H3MMP2
SCHEMBL21328505 0.66 NR1H2 (0.40) MMP9NR1H2NR1H3MMP2
SCHEMBL5153924 0.65 ACHE (0.38) MMP9NR1H2NR1H3MMP2
SCHEMBL21328509 0.63 NR1H2 (0.37) MMP9NR1H2NR1H3MMP2
SCHEMBL11746059 0.63 ALDH1A1 (0.57) NR1H2NR1H3
SCHEMBL10799337 0.63 ALDH1A1 (0.44) NR1H2NR1H3
P-Xylene SCHEMBL27502894 0.63 TSHR (0.53) MMP9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7253243-B2 Organosilicon compounds and method of manufacturing the same JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) 2007-08-07 US disclosed