SCHEMBL14429486

SCHEMBL14429486

Cc1cccc(C(=O)Nc2cc(-c3cccc(Cl)c3)ccc2C=O)c1C

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNMA1 Q12791 1/20 0.44
ALDH1A1 P00352 3/20 0.42
NPC1 O15118 3/20 0.41
RAB9A P51151 2/20 0.41
LMNA P02545 1/20 0.41
TP53 P04637 1/20 0.41
TSHR P16473 1/20 0.41
HTT P42858 1/20 0.41
HSD17B10 Q99714 1/20 0.41
CTSV O60911 1/20 0.41
CTSL P07711 1/20 0.41
CTSS P25774 1/20 0.41
PTGER4 P35408 1/20 0.41
PTGER2 P43116 1/20 0.41
GRM5 P41594 1/20 0.41
S1PR4 O95977 1/20 0.41
ACLY P53396 2/20 0.40
ESR2 Q92731 1/20 0.40
SUCNR1 Q9BXA5 2/20 0.40
HPGD P15428 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2276321 0.86 ACLY (0.56) KCNMA1NPC1RAB9APTGER4PTGER2
SCHEMBL12394970 0.81 ALDH1A1 (0.51) ALDH1A1NPC1RAB9ALMNATP53
SCHEMBL2269657 0.81 ALDH1A1 (0.45) KCNMA1ALDH1A1NPC1RAB9ALMNA
SCHEMBL14428158 0.78 MAPT (0.43) ALDH1A1NPC1RAB9ALMNATP53
SCHEMBL14428153 0.77 KCNMA1 (0.51) KCNMA1LMNATP53GRM5ACLY
SCHEMBL12394956 0.77 MAOB (0.53) ALDH1A1NPC1RAB9ALMNATP53
SCHEMBL2275722 0.76 ACLY (0.57) NPC1RAB9ALMNATP53TSHR
SCHEMBL12166013 0.74 ACLY (0.53) KCNMA1ACLYSUCNR1MEN1KMT2A
SCHEMBL12117713 0.73 ALDH1A1 (0.50) ALDH1A1NPC1RAB9ALMNATP53
SCHEMBL13825831 0.73 ESR2 (0.57) ALDH1A1NPC1RAB9ATSHRESR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed