Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | MMP14 | P50281 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | PNMT | P11086 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14434600 | 0.77 | TRPV4 (0.47) | ALDH1A1TSHRCYP3A4MMP9MMP8 | |
| SCHEMBL29028384 | 0.77 | LMNA (0.62) | ALDH1A1TSHRCYP3A4KDM4ELMNA | |
| SCHEMBL4579440 | 0.74 | ALDH1A1 (0.45) | ALDH1A1TSHRCYP3A4MMP9MMP8 | |
| SCHEMBL27926017 | 0.73 | CYP3A4 (0.58) | ALDH1A1TSHRCYP3A4MMP9MMP8 | |
| SCHEMBL28830609 | 0.73 | KMT2A (0.51) | ALDH1A1TSHRCYP3A4HTTKMT2A | |
| SCHEMBL11138032 | 0.72 | MMP9 (0.42) | ALDH1A1TSHRCYP3A4MMP9MMP8 | |
| SCHEMBL30811569 | 0.70 | HTT (0.43) | ALDH1A1TSHRKDM4ELMNAHTT | |
| SCHEMBL24487385 | 0.70 | CYP3A4 (0.44) | ALDH1A1TSHRCYP3A4MMP9MMP8 | |
| SCHEMBL5911270 | 0.68 | CYP3A4 (0.66) | ALDH1A1TSHRCYP3A4MMP9MMP8 | |
| SCHEMBL4953745 | 0.68 | MMP9 (0.46) | ALDH1A1CYP3A4MMP9MMP8MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076055-A9 | COMPOSITIONS AND METHODS COMPRISING PROTEINASE ACTIVATED RECEPTOR ANTAGONISTS | ENTREMED INC (US) | 2007-08-30 | — | — | WO | disclosed |