Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 2/20 | 0.58 |
| ▸ | CA1 | P00915 | 2/20 | 0.58 |
| ▸ | CA2 | P00918 | 2/20 | 0.58 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HTR6 | P50406 | 2/20 | 0.44 |
| ▸ | CA5A | P35218 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2877986 | 0.75 | CA12 (0.54) | CA12CA1CA2CA14SMN1; SMN2 | |
| SCHEMBL3274365 | 0.72 | SMN1; SMN2 (0.46) | CA12CA1CA2CA14SMN1; SMN2 | |
| SCHEMBL4617629 | 0.72 | SFRP1 (0.54) | CA12CA1CA2CA14SMN1; SMN2 | |
| SCHEMBL2944179 | 0.71 | CYP19A1 (0.60) | ALDH1A1 | |
| SCHEMBL14434270 | 0.71 | KMT2A (0.52) | CA12CA1CA2SMN1; SMN2CA9 | |
| SCHEMBL14768749 | 0.70 | CA12 (0.58) | CA12CA1CA2CA14HTR2A | |
| SCHEMBL4616546 | 0.69 | SFRP1 (0.55) | SMN1; SMN2HTR6KDM4ESFRP1ALDH1A1 | |
| SCHEMBL14433971 | 0.69 | LMNA (0.51) | SMN1; SMN2GLAHTR6LMNAPOLB | |
| SCHEMBL18498648 | 0.69 | SLC6A9 (0.45) | CA1CA2SMN1; SMN2GLAGAA | |
| SCHEMBL464374 | 0.68 | CA12 (0.54) | CA12CA1CA2CA14SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076055-A9 | COMPOSITIONS AND METHODS COMPRISING PROTEINASE ACTIVATED RECEPTOR ANTAGONISTS | ENTREMED INC (US) | 2007-08-30 | — | — | WO | disclosed |
| WO-2007076055-A2 | COMPOSITIONS AND METHODS COMPRISING PROTEINASE ACTIVATED RECEPTOR ANTAGONISTS | ENTREMED, INC. (US) | 2007-07-05 | — | — | WO | disclosed |