Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | ALPL | P05186 | 4/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | HTR6 | P50406 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14433513 | 0.79 | SMN1; SMN2 (0.52) | LMNASMN1; SMN2TSHRHTTPOLB | |
| SCHEMBL7113124 | 0.77 | SMN1; SMN2 (0.59) | LMNASMN1; SMN2TP53PKMMAPT | |
| SCHEMBL1512014 | 0.75 | SLC6A9 (0.44) | LMNASMN1; SMN2TSHRGLAMAPT | |
| SCHEMBL5780703 | 0.70 | HTR6 (0.54) | LMNASMN1; SMN2TP53THRBHTR6 | |
| SCHEMBL18530464 | 0.69 | ALPL (0.70) | LMNASMN1; SMN2HTTALPLTP53 | |
| SCHEMBL3274365 | 0.69 | SMN1; SMN2 (0.46) | LMNASMN1; SMN2GLAPOLB | |
| SCHEMBL707800 | 0.69 | PTPN1 (0.40) | LMNASMN1; SMN2TSHRGLA | |
| SCHEMBL20523714 | 0.69 | LMNA (0.46) | LMNASMN1; SMN2TSHRHTTTP53 | |
| SCHEMBL14433909 | 0.69 | CA12 (0.58) | LMNASMN1; SMN2GLAHTR6POLB | |
| SCHEMBL6534311 | 0.68 | PTPN1 (0.42) | LMNASMN1; SMN2TSHRHTTGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007076055-A9 | COMPOSITIONS AND METHODS COMPRISING PROTEINASE ACTIVATED RECEPTOR ANTAGONISTS | ENTREMED INC (US) | 2007-08-30 | — | — | WO | disclosed |
| WO-2007076055-A2 | COMPOSITIONS AND METHODS COMPRISING PROTEINASE ACTIVATED RECEPTOR ANTAGONISTS | ENTREMED, INC. (US) | 2007-07-05 | — | — | WO | disclosed |