Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 15/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5322616 | 0.81 | RXRA (0.51) | DRD2HTR2AHTR2CCYP2C9EPHX2 | |
| SCHEMBL14435512 | 0.80 | HTR2A (0.48) | DRD2HTR2AHTR2CHRH3CYP2C9 | |
| SCHEMBL14435117 | 0.78 | CNR2 (0.45) | DRD2HTR2AHTR2CHRH3CNR2 | |
| SCHEMBL5322650 | 0.78 | NPSR1 (0.48) | DRD2HTR2AHTR2CCYP2C9EPHX2 | |
| SCHEMBL14435513 | 0.77 | HTR2A (0.40) | DRD2HTR2AHTR2CHRH3CYP2C9 | |
| SCHEMBL14435508 | 0.76 | EPHX2 (0.48) | DRD2HTR2AHTR2CHRH3CYP2C9 | |
| SCHEMBL5325795 | 0.76 | HTR2A (0.44) | DRD2HTR2AHTR2CHRH3CYP2C9 | |
| SCHEMBL14435511 | 0.74 | ALDH1A1 (0.49) | NPC1RAB9AHRH3CYP2C9EPHX2 | |
| SCHEMBL14435510 | 0.74 | HTR2A (0.42) | NPC1RAB9ADRD2HTR2AHTR2C | |
| SCHEMBL14435114 | 0.73 | HTR2A (0.43) | NPC1RAB9ADRD2HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007088462-A1 | SPIROCHROMANE ANTAGONISTS OF THE H-3 RECEPTOR | PFIZER PRODUCTS INC. (US) | 2007-08-09 | — | — | WO | disclosed |