Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.39 |
| ▸ | ITK | Q08881 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14435513 | 0.80 | HTR2A (0.40) | HPGDDRD2HTR2AHTR2CALDH1A1 | |
| SCHEMBL5322616 | 0.78 | RXRA (0.51) | DRD2HTR2AHTR2CHDAC3HDAC4 | |
| SCHEMBL14435119 | 0.78 | NPC1 (0.48) | DRD2HTR2AHTR2CEPHX2CYP2C9 | |
| SCHEMBL14435512 | 0.77 | HTR2A (0.48) | DRD2HTR2AHTR2CHDAC3HDAC4 | |
| SCHEMBL14435508 | 0.74 | EPHX2 (0.48) | DRD2HTR2AHTR2CHDAC3HDAC4 | |
| SCHEMBL5325795 | 0.71 | HTR2A (0.44) | DRD2HTR2AHTR2CHDAC3HDAC4 | |
| SCHEMBL14435114 | 0.71 | HTR2A (0.43) | HPGDDRD2HTR2AHTR2CALDH1A1 | |
| SCHEMBL5320769 | 0.70 | GPR119 (0.54) | DRD2HTR2AHTR2CHDAC3HDAC4 | |
| SCHEMBL14435510 | 0.70 | HTR2A (0.42) | DRD2HTR2AHTR2CHDAC3HDAC4 | |
| SCHEMBL14435509 | 0.69 | TAS1R3 (0.42) | DRD2HTR2AHTR2CHDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007088462-A1 | SPIROCHROMANE ANTAGONISTS OF THE H-3 RECEPTOR | PFIZER PRODUCTS INC. (US) | 2007-08-09 | — | — | WO | claimed |
| WO-2007088462-A1 | SPIROCHROMANE ANTAGONISTS OF THE H-3 RECEPTOR | PFIZER PRODUCTS INC. (US) | 2007-08-09 | — | — | WO | disclosed |
| WO-2007088462-A1 | SPIROCHROMANE ANTAGONISTS OF THE H-3 RECEPTOR | PFIZER PRODUCTS INC. (US) | 2007-08-09 | — | — | WO | disclosed |