Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 4/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | HTR2A | P28223 | 4/20 | 0.46 |
| ▸ | DRD2 | P14416 | 3/20 | 0.46 |
| ▸ | HTR2C | P28335 | 3/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.41 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.41 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.41 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5322616 | 0.85 | RXRA (0.51) | EPHX2CYP2C9HTR2ADRD2HTR2C | |
| SCHEMBL14435512 | 0.84 | HTR2A (0.48) | EPHX2CYP2C9HTR2ADRD2HTR2C | |
| SCHEMBL14435507 | 0.82 | EPHX2 (0.42) | EPHX2CYP2C9HTR2ADRD2HTR2C | |
| SCHEMBL14435117 | 0.82 | CNR2 (0.45) | EPHX2CYP2C9HTR2ADRD2HTR2C | |
| SCHEMBL5325795 | 0.82 | HTR2A (0.44) | EPHX2CYP2C9HTR2ADRD2HTR2C | |
| SCHEMBL14435511 | 0.80 | ALDH1A1 (0.49) | EPHX2CYP2C9EPHX1HRH3 | |
| SCHEMBL14435114 | 0.77 | HTR2A (0.43) | EPHX2CYP2C9HTR2ADRD2HTR2C | |
| SCHEMBL14435119 | 0.76 | NPC1 (0.48) | EPHX2CYP2C9HTR2ADRD2HTR2C | |
| SCHEMBL14435510 | 0.76 | HTR2A (0.42) | EPHX2CYP2C9HTR2ADRD2HTR2C | |
| SCHEMBL5320036 | 0.74 | SIGMAR1 (0.46) | HTR2ADRD2HTR2CHDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007088462-A1 | SPIROCHROMANE ANTAGONISTS OF THE H-3 RECEPTOR | PFIZER PRODUCTS INC. (US) | 2007-08-09 | — | — | WO | disclosed |