SCHEMBL144363

SCHEMBL144363

CC(=O)c1ccc(N(C)C)cc1O

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 8/20 0.57
MAOA P21397 4/20 0.57
KLKB1 P03952 1/20 0.54
ALDH1A1 P00352 4/20 0.53
HPGD P15428 3/20 0.53
MAPT P10636 3/20 0.53
NPC1 O15118 2/20 0.53
MEN1 O00255 1/20 0.53
TP53 P04637 1/20 0.53
KMT2A Q03164 1/20 0.53
SMN1; SMN2 Q16637 1/20 0.53
MAPK1 P28482 2/20 0.52
CYP3A4 P08684 1/20 0.52
PRKDC P78527 1/20 0.42
KDM4E B2RXH2 1/20 0.42
RAB9A P51151 1/20 0.42
HSP90AA1 P07900 1/20 0.41
PDK2 Q15119 1/20 0.41
HTT P42858 1/20 0.41
TSHR P16473 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30728533 1.00 MAOB (0.57) MAOBMAOAKLKB1ALDH1A1HPGD
SCHEMBL22939649 0.86 ALDH1A1 (0.64) MAOBMAOAKLKB1ALDH1A1HPGD
SCHEMBL11108442 0.84 MAOA (0.45) MAOBMAOAKLKB1ALDH1A1HPGD
SCHEMBL729586 0.84 MAOA (0.57) MAOBMAOAKLKB1ALDH1A1HPGD
SCHEMBL12316301 0.82 MAOA (0.55) MAOBMAOAKLKB1ALDH1A1HPGD
SCHEMBL22939522 0.79 MEN1 (0.76) MAOBMAOAKLKB1ALDH1A1HPGD
SCHEMBL3165135 0.79 CA12 (0.62) MAOBMAOAKLKB1ALDH1A1HPGD
SCHEMBL8072839 0.79 MEN1 (0.61) MAOBMAOAALDH1A1HPGDMAPT
SCHEMBL12387052 0.79 CA12 (0.66) MAOBMAOAKLKB1ALDH1A1HPGD
SCHEMBL10737973 0.78 KLKB1 (0.42) MAOBMAOAKLKB1ALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240058480-A1 CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT THE GENERAL HOSPITAL CORPORATION 2024-02-22 US disclosed
US-11801316-B2 Cromolyn derivatives and related methods of imaging and treatment THE GENERAL HOSPITAL CORPORATION (US) 2023-10-31 US disclosed
US-11666669-B2 Cromolyn derivatives and related methods of imaging and treatment THE GENERAL HOSPITAL CORPORATION (US) 2023-06-06 US disclosed
US-20210363124-A1 HETEROCYCLYL POLYMETHINE IR CHROMOPHORES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2021-11-25 US disclosed
WO-2020118116-A1 HETEROCYCLYL POLYMETHINE IR CHROMOPHORES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2020-06-11 WO disclosed
US-20200140404-A1 HETEROCYCLYL POLYMETHINE IR CHROMOPHORES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2020-05-07 US disclosed
US-10576171-B2 Cromolyn derivatives and related methods of imaging and treatment THE GENERAL HOSPITAL CORPORATION (US) 2020-03-03 US disclosed
EP-3567033-A1 CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT The General Hospital Corporation (US) 2019-11-13 EP disclosed
US-20190231910-A1 CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT THE GENERAL HOSPITAL CORPORATION 2019-08-01 US disclosed
US-10251961-B2 Cromolyn derivatives and related methods of imaging and treatment THE GENERAL HOSPITAL CORPORATION (US) 2019-04-09 US disclosed
US-20180169277-A1 CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT THE GENERAL HOSPITAL CORPORATION 2018-06-21 US disclosed
US-9925282-B2 Cromolyn derivatives and related methods of imaging and treatment THE GENERAL HOSPITAL CORPORATION (US) 2018-03-27 US disclosed
US-20160263257-A1 CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT THE GENERAL HOSPITAL CORPORATION 2016-09-15 US disclosed
EP-3060205-A1 CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT The General Hospital Corporation DBA Massachusetts (US) 2016-08-31 EP disclosed
WO-2015061397-A1 CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT THE GENERAL HOSTPITAL CORPORATION (US) 2015-04-30 WO disclosed
US-20140140927-A1 CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT THE GENERAL HOSPITAL CORPORATION (US) 2014-05-22 US disclosed
US-8617517-B2 Cromolyn derivatives and related methods of imaging and treatment THE GENERAL HOSPITAL CORPORATION (US) 2013-12-31 US disclosed
US-20120058049-A1 CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT THE GENERAL HOSPITAL CORPORATION 2012-03-08 US disclosed
EP-2391618-A2 CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT The General Hospital Corporation (US) 2011-12-07 EP disclosed
WO-2010088455-A2 CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT THE GENERAL HOSPITAL CORPORATION (US) 2010-08-05 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10576171-B2 Cromolyn derivatives and related methods of imaging and treatment PSEN1, PSEN2, CROCC MAOB 341/4885MAOA 334/4885KLKB1 2942/4885
US-11801316-B2 Cromolyn derivatives and related methods of imaging and treatment PSEN1, PSEN2, CROCC MAOB 267/4885MAOA 263/4885KLKB1 2936/4885
US-20240058480-A1 CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT PSEN1, PSEN2, CROCC MAOB 320/4885MAOA 331/4885KLKB1 2936/4885
US-20200140404-A1 HETEROCYCLYL POLYMETHINE IR CHROMOPHORES SMARCE1, SMARCD1, WDR82 MAOB 1310/4885MAOA 1868/4885KLKB1 4330/4885
US-10251961-B2 Cromolyn derivatives and related methods of imaging and treatment PSEN1, PSEN2, CROCC MAOB 267/4885MAOA 263/4885KLKB1 2936/4885
US-20190231910-A1 CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT PSEN1, PSEN2, CROCC MAOB 341/4885MAOA 334/4885KLKB1 2942/4885
US-20140140927-A1 CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT PSEN1, PSEN2, CROCC MAOB 320/4885MAOA 331/4885KLKB1 2936/4885
US-20210363124-A1 HETEROCYCLYL POLYMETHINE IR CHROMOPHORES SMARCE1, CRY2, WDR82 MAOB 1321/4885MAOA 2003/4885KLKB1 3765/4885
US-20160263257-A1 CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT PSEN1, CROCC, PSEN2 MAOB 240/4885MAOA 245/4885KLKB1 3028/4885
US-20120058049-A1 CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT CLN6, CA6, GALNT6 MAOB 1254/4885MAOA 1296/4885KLKB1 3172/4885
US-11666669-B2 Cromolyn derivatives and related methods of imaging and treatment PSEN1, PSEN2, CROCC MAOB 320/4885MAOA 331/4885KLKB1 2936/4885
US-20180169277-A1 CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT PSEN1, PSEN2, CROCC MAOB 267/4885MAOA 263/4885KLKB1 2936/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.