Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | VCP | P55072 | 1/20 | 0.33 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
| ▸ | NOX4 | Q9NPH5 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.31 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.31 |
| ▸ | GCK | P35557 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8349607 | 0.92 | TDP1 (0.32) | TDP1SLC16A3P2RX3NOX4ALOX5AP | |
| SCHEMBL14439828 | 0.91 | TDP1 (0.40) | TDP1VCPTP53MAPTALOX5AP | |
| SCHEMBL6967249 | 0.90 | HSP90B1 (0.33) | TDP1VCPKMT2A | |
| SCHEMBL7164319 | 0.88 | GRM5 (0.32) | SLC16A3P2RX3NOX4TP53TLR7 | |
| SCHEMBL5853114 | 0.88 | TDP1 (0.37) | TDP1VCPTP53MAPTAVPR1A | |
| SCHEMBL6967282 | 0.87 | TDP1 (0.32) | TDP1VCPTP53MAPTKMT2A | |
| SCHEMBL6972460 | 0.86 | P2RX3 (0.36) | TDP1VCPP2RX3TP53MAPT | |
| SCHEMBL6966496 | 0.86 | VCP (0.37) | TDP1VCPTP53MAPT | |
| SCHEMBL14439830 | 0.85 | TP53 (0.39) | TDP1VCPTP53MAPTKMT2A | |
| SCHEMBL14439829 | 0.85 | VCP (0.36) | TDP1VCPTP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |