Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 4/20 | 0.42 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | MELK | Q14680 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14535216 | 0.84 | CHRM5 (0.48) | THRBGAAALDH1A1CHRM5ADRA2C | |
| SCHEMBL7562139 | 0.84 | CHRM5 (0.48) | THRBGAAALDH1A1CHRM5ADRA2C | |
| SCHEMBL2842528 | 0.82 | ACHE (0.47) | CHRM5ADRA2CACHE | |
| SCHEMBL14291740 | 0.80 | ALDH1A1 (0.45) | GAAALDH1A1MEN1KMT2ALMNA | |
| SCHEMBL20025837 | 0.80 | LRRK2 (0.43) | THRBGAAALDH1A1LRRK2CHRM5 | |
| SCHEMBL25856481 | 0.79 | ACHE (0.60) | THRBCHRM5ADRA2CACHELMNA | |
| SCHEMBL12615 | 0.79 | ACHE (0.53) | THRBGAAALDH1A1CHRM5ADRA2C | |
| SCHEMBL12716130 | 0.79 | ACHE (0.53) | THRBGAAALDH1A1CHRM5ADRA2C | |
| SCHEMBL21450694 | 0.79 | THRB (0.41) | THRBGAAALDH1A1CHRM5ADRA2C | |
| SCHEMBL14536447 | 0.76 | KDM4E (0.35) | CHRM5ADRA2CACHEMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7241769-B2 | Pyrimidines as PLK inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-07-10 | — | — | US | disclosed |