SCHEMBL1445604

SCHEMBL1445604

Nc1nc2c(ncn2-n2cnc3c(S)ncnc32)c(=S)[nH]1

nearest known ligand 0.33

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.33
XDH P47989 4/20 0.32
GAA P10253 1/20 0.31
KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8302 0.85 XDH (0.39) ALDH1A1XDHGAAKMT2A
SCHEMBL5607948 0.77 XDH (0.31) ALDH1A1XDHGAA
SCHEMBL1683802 0.77 ADORA2A (0.35)
SCHEMBL9001851 0.73 XDH (0.37) ALDH1A1XDHGAAKMT2A
SCHEMBL3291325 0.70 CDK1 (0.47) ALDH1A1XDHGAAKMT2A
SCHEMBL1831279 0.69 XDH (0.50) ALDH1A1XDHKMT2A
SCHEMBL1901244 0.68 ALDH1A1 (0.32) ALDH1A1
SCHEMBL22901881 0.67 PI4KA (0.47) ALDH1A1XDHGAAKMT2A
SCHEMBL16769795 0.67 CDK2 (0.54) ALDH1A1GAAKMT2A
SCHEMBL29159183 0.67 ALDH1A1 (0.37) ALDH1A1XDHGAAKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0105404-A1 Derivatives of steroid compounds linked to cyotoxic agents and process for their preparation MERCK & CO. INC. (US) 1984-04-18 EP claimed
CN-112584824-B Nanoparticles 新泰福托特股份有限公司 2024-03-29 CN disclosed
CN-116209439-A Substituted N- (2, 6-dioxopiperidin-3-yl) -1, 3-dioxoisoindolin-5-yl) arylsulfonamide analogs as cereblon modulators 圣裘德儿童研究医院有限公司 2023-06-02 CN disclosed
CN-114901366-A RAS inhibitors 锐新医药公司 2022-08-12 CN disclosed
CN-111012921-A Human antibody drug conjugates against tissue factor 根马布股份公司 2020-04-17 CN disclosed
US-8460663-B2 Stabilized liquid anti-RSV antibody formulations MEDIMMUNE, LLC (US) 2013-06-11 US disclosed
US-20120321616-A1 STABILIZED LIQUID ANTI-RSV ANTIBODY FORMULATIONS MEDLMMUNE, LLC (US) 2012-12-20 US disclosed
US-20120183543-A1 DIAGNOSTIC BIOMARKERS FOR FIBROTIC DISORDERS NOVARTIS AG (CH) 2012-07-19 US disclosed
WO-2011037973-A1 \"CLICK\" NANOPARTICLE CONJUGATES NORTHWESTERN UNIVERSITY (US) 2011-03-31 WO disclosed
CN-1901939-A Treatment of Proliferative Diseases Using Antisense IAP Oligomers and Chemotherapeutic Agents AEGERA THERAPEUTICS INC (CA) 2007-01-24 CN disclosed
EP-1451205-A2 ANTISENSE THERAPY USING OLIGONUCLEOTIDES THAT TARGET HUMAN KINESIN GENES FOR TREATMENT OF CANCER CHIRON CORPORATION (US) 2004-09-01 EP disclosed
US-20040009156-A1 Antisense therapy using oligonucleotides that target human kinesin genes for treatment of cancer REINHARD CHRISTOPH (US) 2004-01-15 US disclosed
EP-1372664-A1 USE OF CERTAIN STEROIDS FOR TREATMENT OF BLOOD CELL DEFICIENCIES Hollis-Eden Pharmaceuticals Inc. (US) 2004-01-02 EP disclosed
WO-2003030832-A2 ANTISENSE THERAPY USING OLIGONUCLEOTIDES THAT TARGET HUMAN KINESIN GENES FOR TREATMENT OF CANCER CHIRON CORPORATION (US) 2003-04-17 WO disclosed
WO-2002069977-A1 USE OF CERTAIN STEROIDS FOR TREATMENT OF BLOOD CELL DEFICIENCIES HOLLIS-EDEN PHARMACEUTICALS, INC. (US) 2002-09-12 WO disclosed