Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Pyrimidine SCHEMBL28141456 | 0.73 | XDH (0.36) | ALDH1A1 | |
| SCHEMBL1445604 | 0.68 | ALDH1A1 (0.33) | ALDH1A1 | |
| SCHEMBL9001851 | 0.68 | XDH (0.37) | ALDH1A1 | |
| SCHEMBL5607948 | 0.67 | XDH (0.31) | ALDH1A1 | |
| SCHEMBL27562476 | 0.65 | XDH (0.42) | ALDH1A1 | |
| SCHEMBL16769795 | 0.64 | CDK2 (0.54) | ALDH1A1 | |
| SCHEMBL29159183 | 0.64 | ALDH1A1 (0.37) | ALDH1A1 | |
| SCHEMBL22901881 | 0.64 | PI4KA (0.47) | ALDH1A1 | |
| SCHEMBL22381492 | 0.63 | CDK1 (0.42) | ALDH1A1 | |
| SCHEMBL1746164 | 0.63 | TK1 (0.37) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110112052-A1 | SPIRO-OXINDOLE MDM2 ANTAGONISTS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2011-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110112052-A1 | SPIRO-OXINDOLE MDM2 ANTAGONISTS | TP53, MDM2, TP53BP1 | ALDH1A1 1498/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.