SCHEMBL5607948

SCHEMBL5607948

Nc1nc2c(ncn2-n2cnc3cncnc32)c(=S)[nH]1

nearest known ligand 0.31

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
XDH P47989 2/20 0.31
FDPS P14324 1/20 0.31
GAA P10253 1/20 0.30
ALDH1A1 P00352 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8302 0.84 XDH (0.39) XDHGAAALDH1A1
SCHEMBL523465 0.84 XDH (0.47) XDHALDH1A1
Pyrimidine SCHEMBL28141456 0.81 XDH (0.36) XDHGAAALDH1A1
SCHEMBL27838826 0.79 BLM (0.34) FDPSALDH1A1
SCHEMBL1445604 0.77 ALDH1A1 (0.33) XDHGAAALDH1A1
SCHEMBL1031449 0.77 FDPS (0.43) FDPSALDH1A1
SCHEMBL6036330 0.75 CDK1 (0.44) FDPS
SCHEMBL2120550 0.74 FDPS (0.45) FDPSALDH1A1
SCHEMBL851861 0.73 FDPS (0.32) FDPS
SCHEMBL852593 0.73 HSP90AB1 (0.41)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023198082-A1 NON-LINEAR PEGYLATED LIPID AND APPLICATION THEREOF 厦门赛诺邦格生物科技股份有限公司 2023-10-19 WO disclosed
WO-2023198084-A1 NITROGEN-BRANCHED NONLINEAR PEGYLATED LIPID AND USE THEREOF 厦门赛诺邦格生物科技股份有限公司 2023-10-19 WO disclosed
WO-2023198083-A1 NONLINEAR PEGYLATED LIPID CONTAINING TERTIARY AMINE AND APPLICATION THEREOF 厦门赛诺邦格生物科技股份有限公司 2023-10-19 WO disclosed
WO-2023126006-A1 CATIONIC LIPID CONTAINING FUNCTIONAL GROUP ON SIDE CHAIN, AND USE THEREOF 厦门赛诺邦格生物科技股份有限公司 2023-07-06 WO disclosed
CN-112912395-A anti-GDF 15 antibodies, compositions, and methods of use 辉瑞公司 2021-06-04 CN disclosed
CN-112469418-A Dosing regimens for treating PI3K related disorders 因赛特公司 2021-03-09 CN disclosed
CN-112004848-A Block copolymers and self-assembled nanoparticles formed therefrom 国际商业机器公司 2020-11-27 CN disclosed
CN-104520290-B Amido spirocyclic amide and sulfonamide derivatives 基因科技股份有限公司 2020-10-09 CN disclosed
CN-103717263-B Antibodies that bind OX40 and uses thereof 格兰马克药品股份有限公司 2018-01-12 CN disclosed
CN-103930442-B Anti-CD 40 antibodies, purposes and method 鳄鱼生物科学公司 2017-09-26 CN disclosed
EP-1793830-A2 THERAPEUTIC COMBINATIONS COMPRISING POLY(ADP-RIBOSE) POLYMERASES INHIBITOR Pfizer, Inc. (US) 2007-06-13 EP disclosed
WO-2006033006-A2 THERAPEUTIC COMBINATIONS COMPRISING POLY(ADP-RIBOSE) POLYMERASES INHIBITOR PFIZER INC., (US) 2006-03-30 WO disclosed
EP-0254268-A2 Fluorinated nucleosides,their preparation and their pharmaceutical use against AIDS THE WELLCOME FOUNDATION LIMITED (GB) 1988-01-27 EP disclosed