Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CPN1 | P15169 | 1/20 | 0.45 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | PLAU | P00749 | 2/20 | 0.43 |
| ▸ | MASP2 | O00187 | 1/20 | 0.43 |
| ▸ | THPO | P40225 | 1/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 5/20 | 0.42 |
| ▸ | PRSS3 | P35030 | 5/20 | 0.42 |
| ▸ | PRSS2 | P07478 | 4/20 | 0.42 |
| ▸ | F2 | P00734 | 4/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | ST14 | Q9Y5Y6 | 2/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 2/20 | 0.40 |
| ▸ | F12 | P00748 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10585660 | 0.78 | TYR (0.35) | — | |
| SCHEMBL1505347 | 0.77 | HTT (0.61) | CPN1CPB2LMNAPLAUMASP2 | |
| SCHEMBL14119117 | 0.77 | KIF11 (0.44) | PRSS1PRSS3PRSS2F2ST14 | |
| SCHEMBL8169323 | 0.74 | CPN1 (0.46) | CPN1CPB2LMNAPLAUMASP2 | |
| SCHEMBL12792667 | 0.73 | CPN1 (0.57) | CPN1CPB2LMNAPRSS1PRSS3 | |
| SCHEMBL582044 | 0.73 | ESR1 (0.54) | LMNATHPOALDH1A1HPGDCYP2C19 | |
| SCHEMBL5987630 | 0.73 | MEN1 (0.38) | LMNAALDH1A1 | |
| SCHEMBL11835373 | 0.72 | ALDH1A1 (0.52) | LMNATHPOALDH1A1HPGDHSD17B10 | |
| SCHEMBL537030 | 0.71 | LMNA (0.77) | LMNAPLAUMASP2THPOPRSS1 | |
| SCHEMBL23049360 | 0.71 | PRSS1 (0.48) | CPN1CPB2LMNAPLAUMASP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2366786-A2 | Cytokine receptor modulators and uses thereof | VALORISATION HSJ, Société en Commandite (CA) | 2011-09-21 | — | — | EP | claimed |
| EP-2288621-A2 | IL-23 RECEPTOR ANTAGONISTS AND USES THEREOF | Valorisation HSJ, Societe en Commandite (CA) | 2011-03-02 | — | — | EP | claimed |
| EP-1885855-A4 | CYTOKINE RECEPTOR MODULATORS AND USES THEREOF | VALORISATION HSJ SOC EN COMMAN (CA) | 2009-03-04 | — | — | EP | claimed |
| US-20090048161-A1 | Cytokine receptor modulators and uses thereof | VALORISATION HSJ, SOCIETE EN COMMANDITE (CA) | 2009-02-19 | — | — | US | claimed |
| WO-2009007849-A2 | IL-23 RECEPTOR ANTAGONISTS AND USES THEREOF | VALORISATION HSJ, SOCIETE EN COMMANDITE (CA) | 2009-01-15 | — | — | WO | claimed |
| EP-1751175-A4 | INTERLEUKIN-1 RECEPTOR ANTAGONISTS, COMPOSITIONS, AND METHODS OF TREATMENT | VALORISATION RECH SOC EN COMMA (CA) | 2008-12-17 | — | — | EP | claimed |
| EP-1885855-A2 | CYTOKINE RECEPTOR MODULATORS AND USES THEREOF | VALORISATION HSJ, Société en Commandite (CA) | 2008-02-13 | — | — | EP | claimed |
| EP-1751175-A1 | INTERLEUKIN-1 RECEPTOR ANTAGONISTS, COMPOSITIONS, AND METHODS OF TREATMENT | Valorisation-Recherche, Société en Commandite (CA) | 2007-02-14 | — | — | EP | claimed |
| WO-2007004060-A2 | CYTOKINE RECEPTOR MODULATORS AND USES THEREOF | VALORISATION HSJ, SOCIETE EN COMMANDITE (CA) | 2007-01-11 | — | — | WO | claimed |
| US-20060094663-A1 | Interleukin-1 receptor antagonists, compositions, and methods of treatment | VALORISATION-RECHERCHE, SOCIETE EN COMMANDITE (CA) | 2006-05-04 | — | — | US | claimed |
| WO-2005105830-A1 | INTERLEUKIN-1 RECEPTOR ANTAGONISTS, COMPOSITIONS, AND METHODS OF TREATMENT | VALORISATION-RECHERCHE, SOCIETE EN COMMANDITE (CA) | 2005-11-10 | — | — | WO | claimed |
| US-8802818-B2 | Prostaglandin-F2 alpha receptor modulators and uses thereof | LUBELL WILLIAM D (CA) | 2014-08-12 | — | — | US | disclosed |
| US-8618054-B2 | Interleukin-1 receptor antagonists, compositions, and methods of treatment | Valorisation-Rechereche Société en Commandite (CA) | 2013-12-31 | — | — | US | disclosed |
| US-20120309690-A1 | PROSTAGLANDIN-F2 ALPHA RECEPTOR MODULATORS AND USES THEREOF | LUBELL WILLIAM D (CA) | 2012-12-06 | — | — | US | disclosed |
| EP-1751175-B1 | INTERLEUKIN-1 RECEPTOR ANTAGONISTS, COMPOSITIONS, AND METHODS OF TREATMENT | VALORISATION RECH SOC EN COMMANDITE (CA) | 2012-07-25 | — | — | EP | disclosed |
| EP-1885855-A2 | CYTOKINE RECEPTOR MODULATORS AND USES THEREOF | VALORISATION HSJ, Société en Commandite (CA) | 2008-02-13 | — | — | EP | disclosed |
| EP-1751175-A1 | INTERLEUKIN-1 RECEPTOR ANTAGONISTS, COMPOSITIONS, AND METHODS OF TREATMENT | Valorisation-Recherche, Société en Commandite (CA) | 2007-02-14 | — | — | EP | disclosed |
| WO-2007004060-A2 | CYTOKINE RECEPTOR MODULATORS AND USES THEREOF | VALORISATION HSJ, SOCIETE EN COMMANDITE (CA) | 2007-01-11 | — | — | WO | disclosed |
| US-20060094663-A1 | Interleukin-1 receptor antagonists, compositions, and methods of treatment | VALORISATION-RECHERCHE, SOCIETE EN COMMANDITE (CA) | 2006-05-04 | — | — | US | disclosed |
| WO-2005105830-A1 | INTERLEUKIN-1 RECEPTOR ANTAGONISTS, COMPOSITIONS, AND METHODS OF TREATMENT | VALORISATION-RECHERCHE, SOCIETE EN COMMANDITE (CA) | 2005-11-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120309690-A1 | PROSTAGLANDIN-F2 ALPHA RECEPTOR MODULATORS AND USES THEREOF | PTGFR, PTGER1, PTGER2 | CPN1 2942/4885CPB2 1612/4885LMNA 1707/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.