Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.48 |
| ▸ | NMT2 | O60551 | 3/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.48 |
| ▸ | ADRB3 | P13945 | 3/20 | 0.48 |
| ▸ | NMT1 | P30419 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25669938 | 0.96 | GPR35 (0.54) | GPR35LMNATDP1KMT2AMEN1 | |
| SCHEMBL115418 | 0.94 | GPR35 (0.52) | GPR35LMNATDP1KMT2AMEN1 | |
| SCHEMBL115378 | 0.94 | GPR35 (0.52) | GPR35LMNATDP1KMT2AMEN1 | |
| SCHEMBL116735 | 0.90 | GPR35 (0.66) | GPR35LMNATDP1KMT2AMEN1 | |
| SCHEMBL143979 | 0.90 | GPR35 (0.72) | GPR35LMNATDP1KMT2AMEN1 | |
| SCHEMBL179041 | 0.89 | GPR35 (0.47) | GPR35LMNATDP1KMT2AMEN1 | |
| SCHEMBL21556363 | 0.88 | GPR35 (0.55) | GPR35LMNATDP1KMT2AMEN1 | |
| SCHEMBL25472684 | 0.86 | GPR35 (0.62) | GPR35LMNATDP1KMT2AMEN1 | |
| SCHEMBL26645927 | 0.86 | NMT2 (0.54) | GPR35LMNATDP1KMT2AMEN1 | |
| SCHEMBL26848987 | 0.86 | GPR35 (0.55) | GPR35LMNATDP1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240067635-A1 | CROMOLYN DERIVATIVES AND USES THEREOF | THE GENERAL HOSPITAL CORPORATION | 2024-02-29 | — | — | US | disclosed |
| US-20240058480-A1 | CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT | THE GENERAL HOSPITAL CORPORATION | 2024-02-22 | — | — | US | disclosed |
| US-11801316-B2 | Cromolyn derivatives and related methods of imaging and treatment | THE GENERAL HOSPITAL CORPORATION (US) | 2023-10-31 | — | — | US | disclosed |
| US-11801316-B2 | Cromolyn derivatives and related methods of imaging and treatment | THE GENERAL HOSPITAL CORPORATION (US) | 2023-10-31 | — | — | US | disclosed |
| EP-3506894-B1 | MACROPHAGES/MICROGLIA IN NEURO-INFLAMMATION ASSOCIATED WITH NEURODEGENERATIVE DISEASES | MASSACHUSETTS GEN HOSPITAL (US) | 2023-08-23 | — | — | EP | disclosed |
| US-20230226017-A1 | METHODS OF TREATING A CORONAVIRUS INFECTION | MASSACHUSETTS GEN HOSPITAL (US) | 2023-07-20 | — | — | US | disclosed |
| US-11679095-B2 | Macrophages/microglia in neuro-inflammation associated with neurodegenerative diseases | THE GENERAL HOSPITAL CORPORATION (US) | 2023-06-20 | — | — | US | disclosed |
| US-11666669-B2 | Cromolyn derivatives and related methods of imaging and treatment | THE GENERAL HOSPITAL CORPORATION (US) | 2023-06-06 | — | — | US | disclosed |
| US-11666669-B2 | Cromolyn derivatives and related methods of imaging and treatment | THE GENERAL HOSPITAL CORPORATION (US) | 2023-06-06 | — | — | US | disclosed |
| US-20230149345-A1 | METHODS OF TREATMENT OF CORONAVIRUS-INDUCED INFLAMMATION CONDITIONS | THE GENERAL HOSPITAL CORPORATION | 2023-05-18 | — | — | US | disclosed |
| US-20160263257-A1 | CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT | THE GENERAL HOSPITAL CORPORATION | 2016-09-15 | — | — | US | disclosed |
| US-20160263257-A1 | CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT | THE GENERAL HOSPITAL CORPORATION | 2016-09-15 | — | — | US | disclosed |
| EP-3060205-A1 | CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT | The General Hospital Corporation DBA Massachusetts (US) | 2016-08-31 | — | — | EP | disclosed |
| WO-2015061397-A1 | CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT | THE GENERAL HOSTPITAL CORPORATION (US) | 2015-04-30 | — | — | WO | disclosed |
| US-20140140927-A1 | CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT | THE GENERAL HOSPITAL CORPORATION (US) | 2014-05-22 | — | — | US | disclosed |
| US-20140140927-A1 | CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT | THE GENERAL HOSPITAL CORPORATION (US) | 2014-05-22 | — | — | US | disclosed |
| US-8617517-B2 | Cromolyn derivatives and related methods of imaging and treatment | THE GENERAL HOSPITAL CORPORATION (US) | 2013-12-31 | — | — | US | disclosed |
| US-20120058049-A1 | CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT | THE GENERAL HOSPITAL CORPORATION | 2012-03-08 | — | — | US | disclosed |
| EP-2391618-A2 | CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT | The General Hospital Corporation (US) | 2011-12-07 | — | — | EP | disclosed |
| WO-2010088455-A2 | CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT | THE GENERAL HOSPITAL CORPORATION (US) | 2010-08-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11801316-B2 | Cromolyn derivatives and related methods of imaging and treatment | PSEN1, PSEN2, CROCC | GPR35 339/4885LMNA 62/4885TDP1 2301/4885 |
| US-20240067635-A1 | CROMOLYN DERIVATIVES AND USES THEREOF | PRNP, HTT, CLN6 | GPR35 1991/4885LMNA 111/4885TDP1 978/4885 |
| US-20240058480-A1 | CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT | PSEN1, PSEN2, CROCC | GPR35 332/4885LMNA 45/4885TDP1 2266/4885 |
| US-11679095-B2 | Macrophages/microglia in neuro-inflammation associated with neurodegenerative diseases | CD68, PRNP, HTT | GPR35 1528/4885LMNA 755/4885TDP1 3376/4885 |
| US-20230149345-A1 | METHODS OF TREATMENT OF CORONAVIRUS-INDUCED INFLAMMATION CONDITIONS | C3AR1, IL5, C5 | GPR35 359/4885LMNA 3678/4885TDP1 4796/4885 |
| US-20230226017-A1 | METHODS OF TREATING A CORONAVIRUS INFECTION | CPA3, CMA1, ACE2 | GPR35 1712/4885LMNA 2521/4885TDP1 3569/4885 |
| US-20140140927-A1 | CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT | PSEN1, PSEN2, CROCC | GPR35 332/4885LMNA 45/4885TDP1 2266/4885 |
| US-20160263257-A1 | CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT | PSEN1, CROCC, PSEN2 | GPR35 362/4885LMNA 32/4885TDP1 2625/4885 |
| US-20120058049-A1 | CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT | CLN6, CA6, GALNT6 | GPR35 699/4885LMNA 186/4885TDP1 1467/4885 |
| US-11666669-B2 | Cromolyn derivatives and related methods of imaging and treatment | PSEN1, PSEN2, CROCC | GPR35 332/4885LMNA 45/4885TDP1 2266/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.