Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | GPR6 | P46095 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | CCR3 | P51677 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14469187 | 0.92 | MEN1 (0.43) | ALDH1A1TDP1MTNR1BKDM4ESMN1; SMN2 | |
| SCHEMBL14469170 | 0.88 | KDM4E (0.48) | ALDH1A1MTNR1BKDM4EGPR6SMN1; SMN2 | |
| SCHEMBL14469633 | 0.87 | ALDH1A1 (0.37) | ALDH1A1TDP1MTNR1BKDM4EGPR6 | |
| SCHEMBL14469298 | 0.85 | MEN1 (0.47) | ALDH1A1KDM4ESMN1; SMN2KMT2AMEN1 | |
| SCHEMBL14469573 | 0.85 | MTNR1B (0.39) | ALDH1A1TDP1MTNR1BKDM4ESMN1; SMN2 | |
| SCHEMBL14469580 | 0.84 | L3MBTL1 (0.41) | ALDH1A1SMN1; SMN2TSHRMAPT | |
| SCHEMBL14469188 | 0.84 | ALDH1A1 (0.46) | ALDH1A1KDM4ESMN1; SMN2KMT2AMEN1 | |
| SCHEMBL14469365 | 0.83 | KDM4E (0.48) | ALDH1A1TDP1KDM4ESMN1; SMN2KMT2A | |
| SCHEMBL14469474 | 0.83 | MTNR1B (0.49) | ALDH1A1TDP1MTNR1BKDM4EGPR6 | |
| SCHEMBL14469256 | 0.82 | ALDH1A1 (0.38) | ALDH1A1TDP1MTNR1BKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007075555-A2 | COMBINATION OF AN H3 ANTAGONIST/INVERSE AGONIST AND AN APPETITE SUPPRESSANT | SCHERING CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |