Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14469171 | 0.86 | SMN1; SMN2 (0.38) | KMT2AMEN1GAALMNASMN1; SMN2 | |
| SCHEMBL14469365 | 0.82 | KDM4E (0.48) | KMT2AMEN1TDP1GAALMNA | |
| SCHEMBL14469294 | 0.80 | ALDH1A1 (0.39) | KMT2AMEN1LMNASMN1; SMN2TSHR | |
| SCHEMBL14469188 | 0.80 | ALDH1A1 (0.46) | KMT2AMEN1SMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL14469299 | 0.77 | ALDH1A1 (0.36) | KMT2AMEN1GAALMNASMN1; SMN2 | |
| SCHEMBL14469298 | 0.76 | MEN1 (0.47) | KMT2AMEN1SMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL14456936 | 0.76 | MEN1 (0.47) | KMT2AMEN1TDP1GAALMNA | |
| SCHEMBL14469573 | 0.76 | MTNR1B (0.39) | KMT2AMEN1TDP1SMN1; SMN2TSHR | |
| SCHEMBL14469187 | 0.75 | MEN1 (0.43) | KMT2AMEN1TDP1SMN1; SMN2TSHR | |
| SCHEMBL14469364 | 0.75 | CYP2C19 (0.46) | KMT2ALMNASMN1; SMN2TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007075555-A2 | COMBINATION OF AN H3 ANTAGONIST/INVERSE AGONIST AND AN APPETITE SUPPRESSANT | SCHERING CORPORATION (US) | 2007-07-05 | — | — | WO | disclosed |