Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | NPY1R | P25929 | 1/20 | 0.32 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5621945 | 0.87 | CHRNB2 (0.39) | CHRNB2CHRNA4GPR35ALDH1A1KMT2A | |
| SCHEMBL14458459 | 0.87 | CHRNB2 (0.39) | CHRNB2CHRNA4GPR35ALDH1A1KMT2A | |
| SCHEMBL7909196 | 0.79 | ACHE (0.42) | CHRNB2CHRNA4GPR35ALDH1A1KMT2A | |
| SCHEMBL14474350 | 0.76 | PNMT (0.50) | ADRA2C | |
| SCHEMBL14202528 | 0.75 | CYP2D6 (0.38) | CHRNB2CHRNA4KMT2AMEN1MAPT | |
| SCHEMBL2246781 | 0.74 | GPR35 (0.42) | CHRNB2CHRNA4GPR35ALDH1A1KMT2A | |
| SCHEMBL5916971 | 0.71 | GPR35 (0.46) | CHRNB2CHRNA4GPR35ALDH1A1KMT2A | |
| SCHEMBL5621125 | 0.70 | CHRNB2 (0.40) | CHRNB2CHRNA4GPR35ALDH1A1KMT2A | |
| SCHEMBL5622654 | 0.70 | CHRNB2 (0.40) | CHRNB2CHRNA4GPR35ALDH1A1KMT2A | |
| SCHEMBL12716705 | 0.69 | CHRNB2 (0.39) | CHRNB2CHRNA4GPR35ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070173525-A1 | Tyrosine kinase inhibitors | MERCK SHARP & DOHME CORP. | 2007-07-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070173525-A1 | Tyrosine kinase inhibitors | ABL1, JAK2, ERBB2 | CHRNB2 2871/4885CHRNA4 2174/4885GPR35 1010/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.