SCHEMBL1447652

SCHEMBL1447652

COC(=O)C(C)c1ccc(NC(C)=O)cc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 4/20 0.56
HTT P42858 1/20 0.52
L3MBTL1 Q9Y468 1/20 0.52
MEN1 O00255 5/20 0.50
KMT2A Q03164 5/20 0.50
ALDH1A1 P00352 3/20 0.50
TDP1 Q9NUW8 2/20 0.50
CA12 O43570 1/20 0.50
BRD4 O60885 1/20 0.50
NR1I2 O75469 1/20 0.50
CA1 P00915 1/20 0.50
CA2 P00918 1/20 0.50
MB P02144 1/20 0.50
CYP1A1 P04798 1/20 0.50
CA3 P07451 1/20 0.50
CYP3A4 P08684 1/20 0.50
MAPT P10636 1/20 0.50
RARG P13631 1/20 0.50
TSHR P16473 1/20 0.50
ALOX5AP P20292 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10685509 0.85 LMNA (0.58) SMN1; SMN2HTTL3MBTL1MEN1KMT2A
SCHEMBL261230 0.84 KIF11 (0.60) SMN1; SMN2MEN1KMT2AALDH1A1MAPT
SCHEMBL2172524 0.84 KIF11 (0.60) SMN1; SMN2MEN1KMT2AALDH1A1MAPT
SCHEMBL2170717 0.84 KIF11 (0.60) SMN1; SMN2MEN1KMT2AALDH1A1MAPT
SCHEMBL11804540 0.84 HPGD (0.51) SMN1; SMN2L3MBTL1MEN1KMT2AALDH1A1
SCHEMBL9823526 0.81 POLB (0.58) SMN1; SMN2HTTL3MBTL1MEN1KMT2A
SCHEMBL11272564 0.81 HPGD (0.49) SMN1; SMN2L3MBTL1MEN1KMT2AALDH1A1
SCHEMBL2170844 0.81 ALDH1A1 (0.47) SMN1; SMN2MEN1KMT2AALDH1A1CYP3A4
SCHEMBL262073 0.81 ALDH1A1 (0.47) SMN1; SMN2MEN1KMT2AALDH1A1CYP3A4
SCHEMBL2171946 0.81 ALDH1A1 (0.47) SMN1; SMN2MEN1KMT2AALDH1A1CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8475984-B1 Image holding member for image forming apparatus, process cartridge, and image forming apparatus FUJI XEROX CO., LTD. (JP) 2013-07-02 US disclosed
US-20130164662-A1 IMAGE HOLDING MEMBER FOR IMAGE FORMING APPARATUS, PROCESS CARTRIDGE, AND IMAGE FORMING APPARATUS FUJI XEROX CO., LTD. (JP) 2013-06-27 US disclosed
US-8445900-B2 Organic eletroluminescent element including polyester electronic material and display device including the same FUJI XEROX CO., LTD. (JP) 2013-05-21 US disclosed
US-20130043461-A1 ORGANIC ELECTROLUMINESCENT ELEMENT AND DISPLAY MEDIUM FUJI XEROX CO., LTD. (JP) 2013-02-21 US disclosed
US-20130032789-A1 ORGANIC ELECTROLUMINESCENT ELEMENT AND DISPLAY MEDIUM FUJI XEROX CO., LTD. (JP) 2013-02-07 US disclosed
US-7976959-B2 Organic electroluminescent element including bibenzothiopene containing organic compound and display device including the same FUJI XEROX CO., LTD. (JP) 2011-07-12 US disclosed
US-7910748-B2 Thiophene-containing compound and thiophene-containing compound polymer, organic electroluminescent device, production method thereof, and image display medium FUJI XEROX CO., LTD. (JP) 2011-03-22 US disclosed
US-7902382-B2 Thiophene-containing compound and thiophene-containing compound polymer, organic electroluminescent device, production method thereof, and image display medium FUJI XEROX CO., LTD. (JP) 2011-03-08 US disclosed
CN-101546812-B Organic electroluminescent element and display device including the same FUJI XEROX CO LTD 2010-10-13 CN disclosed
US-20100133995-A1 Novel thiophene-containing compound and thiophene-containing compound polymer, organic electroluminescent device, production method thereof, and image display medium FUJI XEROX CO., LTD. (JP) 2010-06-03 US disclosed
US-20100137553-A1 Novel thiophene-containing compound and thiophene-containing compound polymer, organic electroluminescent device, production method thereof, and image display medium FUJI XEROX CO., LTD. (JP) 2010-06-03 US disclosed
US-7659410-B2 Thiophene-containing compound and thiophene-containing compound polymer, organic electroluminescent device, production method thereof, and image display medium FUJI XEROX CO., LTD. (JP) 2010-02-09 US disclosed
US-20090243469-A1 ORGANIC ELECTROLUMINESCENT ELEMENT AND DISPLAY DEVICE INCLUDING THE SAME FUJI XEROX CO., LTD. (JP) 2009-10-01 US disclosed
CN-101546812-A Organic electroluminescent element and display device including the same FUJI XEROX CO LTD 2009-09-30 CN disclosed
US-20070252519-A1 Novel thiophene-containing compound and thiophene-containing compound polymer, organic electroluminescent device, production method thereof, and image display medium FUJI XEROX CO., LTD. (JP) 2007-11-01 US disclosed
US-4539420-A Optically active 1-aromatic-group-substituted-1-alkanones and methods for their manufacture SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED (BM) 1985-09-03 US disclosed
EP-0151702-A2 Alpha-hydroxyketone acetals SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED (BM) 1985-08-21 EP disclosed
EP-0067698-A2 Optically active 1-aromatic-group-substituted-1-alkanones and methods for their manufacture SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED (BM) 1982-12-22 EP disclosed
EP-0048136-A2 Process for preparing alpha-aromatic group substituted alkanoic acids or esters thereof SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED (BM) 1982-03-24 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070252519-A1 Novel thiophene-containing compound and thiophene-containing compound polymer, organic electroluminescent device, production method thereof, and image display medium ARL1, NOD1, NLRP1 SMN1; SMN2 3896/4885HTT 2109/4885L3MBTL1 2603/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.