Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 11/20 | 0.62 |
| ▸ | THRA | P10827 | 8/20 | 0.62 |
| ▸ | PCNA | P12004 | 8/20 | 0.62 |
| ▸ | LMNA | P02545 | 4/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.62 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.62 |
| ▸ | PPARG | P37231 | 2/20 | 0.62 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.62 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | GABRP | O00591 | 1/20 | 0.62 |
| ▸ | GABRD | O14764 | 1/20 | 0.62 |
| ▸ | F2 | P00734 | 1/20 | 0.62 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.62 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.62 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.62 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8729396 | 0.85 | THRB (0.62) | THRBTHRAPCNALMNAMEN1 | |
| SCHEMBL16416190 | 0.83 | PCNA (0.47) | THRBTHRAPCNALMNAMEN1 | |
| SCHEMBL8766647 | 0.82 | KMT2A (0.43) | THRBTHRAPCNALMNAMEN1 | |
| SCHEMBL3227547 | 0.77 | THRB (0.60) | THRBTHRAPCNALMNAMEN1 | |
| Detrothyronine SCHEMBL8301 | 0.77 | THRB (1.00) | THRBTHRAPCNALMNAMEN1 | |
| Detrothyronine SCHEMBL29651848 | 0.77 | THRB (1.00) | THRBTHRAPCNALMNAMEN1 | |
| Liothyronine SCHEMBL3287278 | 0.77 | THRB (1.00) | THRBTHRAPCNALMNAMEN1 | |
| Liothyronine SCHEMBL29390909 | 0.77 | THRB (1.00) | THRBTHRAPCNALMNAMEN1 | |
| Liothyronine SCHEMBL8300 | 0.77 | THRB (1.00) | THRBTHRAPCNALMNAMEN1 | |
| Rathyronine SCHEMBL123365 | 0.77 | THRB (1.00) | THRBTHRAPCNALMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013006734-A1 | SUBSTITUTED 4-PHENOXYPHENOL ANALOGS AS MODULATORS OF PROLIFERATING CELL NUCLEAR ANTIGEN ACTIVITY | ST. JUDE CHILDREN'S RESEARCH HOSPITAL (US) | 2013-01-10 | — | — | WO | disclosed |