Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 11/20 | 0.62 |
| ▸ | THRA | P10827 | 8/20 | 0.62 |
| ▸ | PCNA | P12004 | 7/20 | 0.62 |
| ▸ | LMNA | P02545 | 4/20 | 0.62 |
| ▸ | POLB | P06746 | 3/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.62 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.62 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.62 |
| ▸ | PPARG | P37231 | 2/20 | 0.62 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.62 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | PGR | P06401 | 1/20 | 0.62 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.62 |
| ▸ | HTR1A | P08908 | 1/20 | 0.62 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.62 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5858330 | 0.89 | THRB (0.52) | THRBTHRAPCNALMNAPOLB | |
| SCHEMBL14485262 | 0.85 | THRB (0.62) | THRBTHRAPCNALMNAPOLB | |
| SCHEMBL3227547 | 0.83 | THRB (0.60) | THRBTHRAPCNALMNAPOLB | |
| SCHEMBL8733106 | 0.81 | THRB (0.39) | THRBTHRAPCNALMNAPOLB | |
| SCHEMBL3222206 | 0.77 | THRB (0.73) | THRBTHRAPCNALMNAPOLB | |
| Tiratricol SCHEMBL743426 | 0.77 | THRB (1.00) | THRBTHRAPCNALMNAPOLB | |
| Tiratricol SCHEMBL30161572 | 0.77 | THRB (1.00) | THRBTHRAPCNALMNAPOLB | |
| Tiratricol SCHEMBL25149 | 0.77 | THRB (1.00) | THRBTHRAPCNALMNAPOLB | |
| Tiratricol SCHEMBL2671904 | 0.76 | THRB (0.97) | THRBTHRAPCNALMNAPOLB | |
| Tiratricol SCHEMBL8660328 | 0.76 | THRB (0.97) | THRBTHRAPCNALMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0831769-A2 | NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS | KARO BIO AB (SE) | 1998-04-01 | — | — | EP | claimed |
| WO-1996040048-A9 | NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS | — | 1997-03-27 | — | — | WO | claimed |
| WO-1996040048-A2 | NOVEL USES FOR THYROID HORMONES OR THYROID HORMONE-LIKE COMPOUNDS | KARO BIO AB (SE) | 1996-12-19 | — | — | WO | claimed |