Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | PNMT | P11086 | 5/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.36 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.35 |
| ▸ | CHRNG | P07510 | 1/20 | 0.35 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.35 |
| ▸ | CHRND | Q07001 | 1/20 | 0.35 |
| ▸ | SLC9A3 | P48764 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14489381 | 0.92 | DRD2 (0.36) | DRD2DRD3PNMTHTR2AHTR2C | |
| SCHEMBL14489427 | 0.91 | PNMT (0.38) | DRD2DRD3PNMTHTR2AHTR2C | |
| SCHEMBL14489380 | 0.90 | DRD2 (0.40) | DRD2DRD3PNMTHTR2AHTR2C | |
| SCHEMBL14489294 | 0.86 | HTR2C (0.36) | DRD2DRD3PNMTHTR2AHTR2C | |
| SCHEMBL14489288 | 0.86 | DRD3 (0.41) | DRD2DRD3PNMTHTR2AHTR2C | |
| SCHEMBL14489151 | 0.86 | TRPM5 (0.41) | DRD2DRD3PNMTHTR2AHTR2C | |
| SCHEMBL14489263 | 0.85 | TRPM5 (0.42) | HTR2AHTR2CHTR2BTRPM5 | |
| SCHEMBL14488879 | 0.85 | SLC6A4 (0.39) | DRD2DRD3PNMTHTR2AHTR2C | |
| SCHEMBL14489506 | 0.83 | KDM1A (0.43) | HTR2AHTR2CHTR2BKDM1AMAOA | |
| SCHEMBL14489202 | 0.83 | DRD2 (0.36) | DRD2DRD3PNMTHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007073503-A2 | INDANE MODULATORS OF GLUCOCORTICOID RECEPTOR, AP-1, AND/OR NF-KB ACTIVITY AND USE THEREOF | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-06-28 | — | — | WO | disclosed |