SCHEMBL14513401

SCHEMBL14513401

N#CN1CCC(NC(=O)Cc2ccccc2)C1

nearest known ligand 0.86

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ USP30 Q70CQ3 14/20 0.86
▸ CTSL P07711 4/20 0.70
▸ CTSB P07858 4/20 0.70
▸ CTSK P43235 3/20 0.70
▸ CTSS P25774 1/20 0.64
▸ CTSC P53634 1/20 0.64
▸ SIGMAR1 Q99720 2/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27305643 1.00 USP30 (0.86) USP30CTSLCTSBCTSKCTSS
SCHEMBL18115519 0.92 USP30 (1.00) USP30CTSLCTSBCTSKCTSS
SCHEMBL6851774 0.82 CTSL (1.00) USP30CTSLCTSBCTSKCTSS
SCHEMBL6851697 0.81 CTSB (1.00) USP30CTSLCTSBCTSKCTSS
SCHEMBL6858432 0.77 CTSL (0.66) USP30CTSLCTSBCTSKCTSS
Cyanamide SCHEMBL6859700 0.77 CTSB (0.92) USP30CTSLCTSBCTSKCTSS
SCHEMBL21324958 0.77 CTSB (0.93) USP30CTSLCTSBCTSKCTSS
SCHEMBL18115550 0.77 USP30 (1.00) USP30CTSLCTSBCTSKCTSS
SCHEMBL6858886 0.76 CTSB (1.00) USP30CTSLCTSBCTSKCTSS
SCHEMBL7009469 0.76 CTSB (1.00) USP30CTSLCTSBCTSKCTSS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070123483-A1 Method and composition for treating obesity by targeting cathespin NMPI, LLC 2007-05-31 — — US disclosed
US-20070123483-A1 Method and composition for treating obesity by targeting cathespin NMPI, LLC 2007-05-31 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070123483-A1 Method and composition for treating obesity by targeting cathespin CTSS, PRKCSH, CTSG USP30 1836/4885CTSL 16/4885CTSB 10/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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