Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 13/20 | 0.56 |
| ▸ | FABP4 | P15090 | 2/20 | 0.56 |
| ▸ | FABP3 | P05413 | 1/20 | 0.54 |
| ▸ | NR4A1 | P22736 | 3/20 | 0.52 |
| ▸ | NR4A3 | Q92570 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | RXRA | P19793 | 6/20 | 0.47 |
| ▸ | RXRB | P28702 | 6/20 | 0.47 |
| ▸ | RXRG | P48443 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.47 |
| ▸ | C5 | P01031 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31744298 | 0.80 | RXRA (0.58) | NR4A2FABP4FABP3RXRARXRB | |
| SCHEMBL7102799 | 0.79 | USP1 (0.54) | NR4A2FABP4FABP3NR4A1NR4A3 | |
| SCHEMBL14528593 | 0.79 | NR4A2 (0.60) | NR4A2FABP4FABP3NR4A1NR4A3 | |
| SCHEMBL13789731 | 0.78 | CASP3 (0.53) | NR4A2FABP4FABP3NR4A1NR4A3 | |
| SCHEMBL14528594 | 0.78 | FABP4 (0.49) | NR4A2FABP4FABP3NR4A1NR4A3 | |
| SCHEMBL14528513 | 0.78 | FABP4 (0.67) | NR4A2FABP4FABP3NR4A1NR4A3 | |
| SCHEMBL11612245 | 0.78 | NPC1 (0.50) | NR4A2FABP4FABP3KDM4EPOLB | |
| SCHEMBL11527476 | 0.76 | NPC1 (0.61) | NR4A2FABP4FABP3NR4A1NR4A3 | |
| SCHEMBL9007064 | 0.76 | FABP4 (0.52) | NR4A2FABP4FABP3NR4A1NR4A3 | |
| SCHEMBL9428424 | 0.75 | FABP4 (0.61) | NR4A2FABP4FABP3NR4A1NR4A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1181014-B1 | HETEROCYCLIC CONTAINING BIPHENYL aP2 INHIBITORS AND METHOD | BRISTOL MYERS SQUIBB CO (US) | 2007-05-23 | — | — | EP | disclosed |