Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 10/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.45 |
| ▸ | AURKA | O14965 | 3/20 | 0.45 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.40 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8240997 | 0.89 | AURKB (0.57) | TTKAURKBAURKAIRAK4IRAK1 | |
| SCHEMBL8246569 | 0.83 | AURKA (0.61) | TTKAURKBAURKAIRAK4IRAK1 | |
| SCHEMBL14530017 | 0.81 | FLT3 (0.56) | TTKAURKBAURKAADORA3 | |
| SCHEMBL14536949 | 0.78 | TTK (0.46) | TTKAURKBAURKA | |
| SCHEMBL14537008 | 0.77 | AURKA (0.46) | TTKAURKBAURKA | |
| SCHEMBL14537009 | 0.77 | FLT3 (0.46) | TTKAURKBAURKAADORA3 | |
| SCHEMBL14537079 | 0.76 | TTK (0.55) | TTKAURKBAURKA | |
| SCHEMBL14529893 | 0.74 | ADORA3 (0.48) | TTKAURKBAURKAADORA3 | |
| SCHEMBL13954859 | 0.72 | FLT3 (0.47) | TTKAURKBAURKAADORA3 | |
| SCHEMBL14529894 | 0.71 | AURKA (0.42) | TTKAURKBAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007058873-A2 | IMIDAZOPYRAZINES AS CYCLIN DEPENTEND KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-05-24 | — | — | WO | disclosed |
| WO-2007056468-A1 | METHODS FOR INHIBITING PROTEIN KINASES | SCHERING CORPORATION (US) | 2007-05-18 | — | — | WO | disclosed |