Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 6/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.42 |
| ▸ | TTK | P33981 | 10/20 | 0.40 |
| ▸ | FLT3 | P36888 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14536949 | 0.82 | TTK (0.46) | AURKAAURKBTTKFLT3 | |
| SCHEMBL14537008 | 0.80 | AURKA (0.46) | AURKAAURKBTTKFLT3 | |
| SCHEMBL14537079 | 0.76 | TTK (0.55) | AURKAAURKBTTKFLT3 | |
| SCHEMBL14537009 | 0.74 | FLT3 (0.46) | AURKAAURKBTTKFLT3 | |
| SCHEMBL14536959 | 0.74 | TTK (0.54) | AURKAAURKBTTK | |
| SCHEMBL14530182 | 0.74 | AURKA (0.53) | AURKAAURKBTTKFLT3 | |
| SCHEMBL14536772 | 0.73 | AURKA (0.51) | AURKAAURKBTTKFLT3 | |
| SCHEMBL14536731 | 0.72 | AURKA (0.49) | AURKAAURKBTTKFLT3 | |
| SCHEMBL14529893 | 0.72 | ADORA3 (0.48) | AURKAAURKBTTKFLT3 | |
| SCHEMBL14538587 | 0.72 | AURKA (0.44) | AURKAAURKBTTKFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007058873-A2 | IMIDAZOPYRAZINES AS CYCLIN DEPENTEND KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-05-24 | — | — | WO | disclosed |