Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 7/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.44 |
| ▸ | TTK | P33981 | 6/20 | 0.41 |
| ▸ | FLT3 | P36888 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8241637 | 0.86 | AURKA (0.60) | AURKAAURKBTTKFLT3CCNA2 | |
| SCHEMBL14536959 | 0.86 | TTK (0.54) | AURKAAURKBTTK | |
| SCHEMBL14530182 | 0.81 | AURKA (0.53) | AURKAAURKBTTKFLT3 | |
| SCHEMBL14536759 | 0.81 | AURKA (0.42) | AURKAAURKBTTKFLT3 | |
| SCHEMBL14537007 | 0.81 | AURKA (0.48) | AURKAAURKBTTKCCNA2CDK2 | |
| SCHEMBL14537040 | 0.81 | AURKA (0.48) | AURKAAURKBTTK | |
| SCHEMBL14537008 | 0.80 | AURKA (0.46) | AURKAAURKBTTKFLT3 | |
| SCHEMBL13954584 | 0.80 | AURKA (0.53) | AURKAAURKBTTKFLT3 | |
| SCHEMBL14536794 | 0.80 | AURKA (0.48) | AURKAAURKBTTKFLT3 | |
| SCHEMBL14536834 | 0.80 | AURKA (0.41) | AURKAAURKBTTKMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007058942-A2 | IMIDAZOPYRAZINES AS PROTEIN KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-05-24 | — | — | WO | disclosed |