Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 7/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.42 |
| ▸ | MAPKAPK5 | Q8IW41 | 7/20 | 0.41 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.40 |
| ▸ | TTK | P33981 | 1/20 | 0.37 |
| ▸ | WEE1 | P30291 | 2/20 | 0.36 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8247437 | 0.90 | AURKA (0.57) | AURKAAURKBMAPKAPK5PTK6FYN | |
| SCHEMBL14537084 | 0.84 | AURKA (0.46) | AURKAAURKB | |
| SCHEMBL14537083 | 0.83 | PTK6 (0.56) | AURKAAURKBMAPKAPK5PTK6 | |
| SCHEMBL14537040 | 0.78 | AURKA (0.48) | AURKAAURKBMAPKAPK5PTK6TTK | |
| SCHEMBL14530182 | 0.77 | AURKA (0.53) | AURKAAURKBMAPKAPK5TTKFYN | |
| SCHEMBL14536959 | 0.77 | TTK (0.54) | AURKAAURKBMAPKAPK5TTKFYN | |
| SCHEMBL8426888 | 0.77 | AURKA (0.58) | AURKAAURKBMAPKAPK5PTK6 | |
| SCHEMBL14530183 | 0.77 | AURKA (0.45) | AURKAAURKBMAPKAPK5PTK6TTK | |
| SCHEMBL14537044 | 0.77 | AURKA (0.45) | AURKAAURKBMAPKAPK5PTK6TTK | |
| SCHEMBL14536795 | 0.77 | MAPKAPK5 (0.54) | AURKAAURKBMAPKAPK5PTK6FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007058873-A2 | IMIDAZOPYRAZINES AS CYCLIN DEPENTEND KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-05-24 | — | — | WO | disclosed |