Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 3/20 | 0.46 |
| ▸ | TYRO3 | Q06418 | 17/20 | 0.45 |
| ▸ | MERTK | Q12866 | 17/20 | 0.45 |
| ▸ | AXL | P30530 | 16/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8240279 | 0.90 | AURKA (0.58) | AURKATYRO3MERTKAXLAURKB | |
| SCHEMBL14530385 | 0.84 | AURKA (0.45) | AURKAAURKB | |
| SCHEMBL14536795 | 0.79 | MAPKAPK5 (0.54) | AURKAAURKB | |
| SCHEMBL13954861 | 0.79 | AURKB (0.56) | AURKAAURKB | |
| SCHEMBL14537040 | 0.79 | AURKA (0.48) | AURKAAURKB | |
| SCHEMBL14536762 | 0.78 | AURKA (0.45) | AURKAAURKB | |
| SCHEMBL14536959 | 0.78 | TTK (0.54) | AURKAAURKB | |
| SCHEMBL14530182 | 0.78 | AURKA (0.53) | AURKAAURKB | |
| SCHEMBL14537044 | 0.77 | AURKA (0.45) | AURKAAURKB | |
| SCHEMBL8426888 | 0.77 | AURKA (0.58) | AURKATYRO3MERTKAXLAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007056468-A1 | METHODS FOR INHIBITING PROTEIN KINASES | SCHERING CORPORATION (US) | 2007-05-18 | — | — | WO | disclosed |