Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 7/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.42 |
| ▸ | TTK | P33981 | 6/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.32 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8247408 | 0.88 | AURKA (0.56) | AURKAAURKBTTKALDH1A1HTT | |
| SCHEMBL14536959 | 0.80 | TTK (0.54) | AURKAAURKBTTK | |
| SCHEMBL13954989 | 0.79 | PRMT5 (0.33) | AURKAAURKBALDH1A1HTTKDM4E | |
| SCHEMBL14536834 | 0.78 | AURKA (0.41) | AURKAAURKBTTK | |
| SCHEMBL14538587 | 0.78 | AURKA (0.44) | AURKAAURKBTTKFLT3 | |
| SCHEMBL14530182 | 0.78 | AURKA (0.53) | AURKAAURKBTTKFLT3 | |
| SCHEMBL14537007 | 0.78 | AURKA (0.48) | AURKAAURKBTTKMAP4K4 | |
| SCHEMBL14537008 | 0.77 | AURKA (0.46) | AURKAAURKBTTKFLT3 | |
| SCHEMBL13954584 | 0.77 | AURKA (0.53) | AURKAAURKBTTKFLT3 | |
| SCHEMBL14536759 | 0.76 | AURKA (0.42) | AURKAAURKBTTKFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007056468-A1 | METHODS FOR INHIBITING PROTEIN KINASES | SCHERING CORPORATION (US) | 2007-05-18 | — | — | WO | disclosed |