Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 6/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.36 |
| ▸ | TTK | P33981 | 5/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SYK | P43405 | 3/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | CCR4 | P51679 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8246844 | 0.88 | AURKA (0.55) | AURKAAURKBPDE4BTTKMEN1 | |
| SCHEMBL13954744 | 0.88 | PDE4B (0.39) | PDE4BMEN1KMT2AP2RX7CCR4 | |
| SCHEMBL14538587 | 0.80 | AURKA (0.44) | AURKAAURKBTTKMEN1KMT2A | |
| SCHEMBL14536959 | 0.79 | TTK (0.54) | AURKAAURKBTTK | |
| SCHEMBL14536759 | 0.79 | AURKA (0.42) | AURKAAURKBTTK | |
| SCHEMBL14537007 | 0.79 | AURKA (0.48) | AURKAAURKBTTK | |
| SCHEMBL14536754 | 0.78 | AURKA (0.42) | AURKAAURKBTTK | |
| SCHEMBL14530182 | 0.77 | AURKA (0.53) | AURKAAURKBTTK | |
| SCHEMBL14537008 | 0.76 | AURKA (0.46) | AURKAAURKBTTK | |
| SCHEMBL13954584 | 0.76 | AURKA (0.53) | AURKAAURKBTTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007056468-A1 | METHODS FOR INHIBITING PROTEIN KINASES | SCHERING CORPORATION (US) | 2007-05-18 | — | — | WO | disclosed |