Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | CDC7 | O00311 | 2/20 | 0.46 |
| ▸ | WEE1 | P30291 | 1/20 | 0.46 |
| ▸ | GALR2 | O43603 | 5/20 | 0.44 |
| ▸ | GALR1 | P47211 | 5/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.41 |
| ▸ | GPR39 | O43194 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31060624 | 0.76 | MAPK8 (0.66) | MAPK8CDC7WEE1GALR2GALR1 | |
| SCHEMBL14024765 | 0.75 | CDC7 (0.57) | MAPK8CDC7WEE1GALR2GALR1 | |
| SCHEMBL27109893 | 0.71 | GPR39 (0.58) | MAPK8AURKBCTSKKDM4EGAA | |
| SCHEMBL21164015 | 0.69 | AURKB (0.42) | MAPK8CDC7WEE1GALR2GALR1 | |
| SCHEMBL25607003 | 0.69 | GPR39 (0.56) | MAPK8AURKBCTSKKDM4EGAA | |
| SCHEMBL14024764 | 0.69 | CDC7 (0.49) | CDC7WEE1CDK1PAK4PAK1 | |
| SCHEMBL28392412 | 0.69 | MAPK8 (0.51) | MAPK8CDC7WEE1GALR2GALR1 | |
| SCHEMBL23587653 | 0.68 | BTK (0.58) | MAPK8AURKBAURKACDK4CDK2 | |
| SCHEMBL91484 | 0.68 | CTSK (0.60) | MAPK8CDC7CTSKKDM4EGAA | |
| SCHEMBL29745053 | 0.67 | SYK (0.62) | CDC7AURKBCDK1CDK2PAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8349859-B2 | Pyrimidine derivatives | HUTCHISON MEDIPHARMA ENTERPRISES LIMITED (BS) | 2013-01-08 | — | — | US | disclosed |