Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 3/20 | 0.46 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.40 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.40 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | F7 | P08709 | 1/20 | 0.39 |
| ▸ | KIFC1 | Q9BW19 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
| ▸ | MMP9 | P14780 | 1/20 | 0.38 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | MMP12 | P39900 | 1/20 | 0.38 |
| ▸ | MMP14 | P50281 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8297783 | 0.90 | MME (0.44) | MMEALDH1A1ROCK2ROCK1ITGB3 | |
| SCHEMBL8297036 | 0.86 | MME (0.48) | MMEROCK2ROCK1ITGB3ITGA2B | |
| SCHEMBL8297654 | 0.84 | ALDH1A1 (0.51) | MMEUTS2RALDH1A1ROCK2ROCK1 | |
| SCHEMBL8295566 | 0.84 | MME (0.42) | MMEUTS2RALDH1A1ROCK2ROCK1 | |
| SCHEMBL14543692 | 0.82 | HTR3A (0.47) | MMEALDH1A1MCHR1 | |
| SCHEMBL8296117 | 0.82 | HTR3A (0.47) | MMEALDH1A1MCHR1 | |
| SCHEMBL8295548 | 0.82 | HTR3A (0.47) | MMEALDH1A1MCHR1 | |
| SCHEMBL14519573 | 0.80 | ROCK2 (0.49) | MMEUTS2RROCK2ROCK1MCHR1 | |
| SCHEMBL8296137 | 0.80 | ROCK2 (0.49) | MMEUTS2RROCK2ROCK1MCHR1 | |
| SCHEMBL8297911 | 0.80 | ROCK2 (0.49) | MMEUTS2RROCK2ROCK1MCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7202269-B2 | GlyT2 modulators | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-04-10 | — | — | US | disclosed |