Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.73 |
| ▸ | PGR | P06401 | 1/20 | 0.73 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.73 |
| ▸ | HTR1A | P08908 | 1/20 | 0.73 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.73 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.73 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.73 |
| ▸ | DRD1 | P21728 | 1/20 | 0.73 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.73 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.73 |
| ▸ | PDE4A | P27815 | 1/20 | 0.73 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.73 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.73 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.73 |
| ▸ | DRD3 | P35462 | 1/20 | 0.73 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.73 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.73 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.73 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.72 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17946258 | 0.97 | ESR1 (0.70) | ESR1PGRCHRM2HTR1AADRA2A | |
| SCHEMBL4401350 | 0.93 | ESR1 (0.64) | ESR1PGRCHRM2HTR1AADRA2A | |
| SCHEMBL14707711 | 0.93 | KDM5A (0.63) | ESR1PGRCHRM2HTR1AADRA2A | |
| SCHEMBL15426058 | 0.92 | ESR1 (0.63) | ESR1PGRCHRM2HTR1AADRA2A | |
| SCHEMBL5225986 | 0.90 | ESR1 (0.73) | ESR1PGRCHRM2HTR1AADRA2A | |
| SCHEMBL2564069 | 0.90 | ESR1 (0.73) | ESR1PGRCHRM2HTR1AADRA2A | |
| SCHEMBL5222962 | 0.89 | ESR1 (0.72) | ESR1PGRCHRM2HTR1AADRA2A | |
| SCHEMBL2564123 | 0.89 | ESR1 (0.72) | ESR1PGRCHRM2HTR1AADRA2A | |
| SCHEMBL31166519 | 0.89 | ESR1 (0.72) | ESR1PGRCHRM2HTR1AADRA2A | |
| SCHEMBL31505225 | 0.89 | ESR1 (0.72) | ESR1PGRCHRM2HTR1AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160272606-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY OXIDATION OF A HYDROXYL GROUP | SANOFI (FR) | 2016-09-22 | — | — | US | disclosed |
| US-9382223-B2 | Process for preparation of dronedarone by oxidation of a hydroxyl group | SANOFI (FR) | 2016-07-05 | — | — | US | disclosed |
| US-9249119-B2 | Process for the preparation of dronedarone by oxidation of a sulphenyl group | SANOFI (FR) | 2016-02-02 | — | — | US | disclosed |
| US-9238636-B2 | Process for preparation of dronedarone by Grignard reaction | SANOFI (FR) | 2016-01-19 | — | — | US | disclosed |
| US-20160009678-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY OXIDATION OF A HYDROXYL GROUP | SANOFI (FR) | 2016-01-14 | — | — | US | disclosed |
| US-20150274688-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY GRIGNARD REACTION | SANOFI (FR) | 2015-10-01 | — | — | US | disclosed |
| US-20150037410-A1 | PHARMACEUTICAL COMPOSITIONS OF RANOLAZINE AND DRONEDARONE | GILEAD SCIENCES, INC. (US) | 2015-02-05 | — | — | US | disclosed |
| US-20150031902-A1 | PROCESS FOR THE PREPARATION OF DRONEDARONE BY OXIDATION OF A SULPHENYL GROUP | SANOFI (FR) | 2015-01-29 | — | — | US | disclosed |
| US-8927743-B2 | Process for obtaining dronedarone | LABORATORIOS LESVI, S.L. (ES) | 2015-01-06 | — | — | US | disclosed |
| US-8796489-B2 | Ketobenzofuran derivatives, method for synthesizing same, and intermediates | SANOFI (FR) | 2014-08-05 | — | — | US | disclosed |
| US-20130142849-A1 | CONTROLLED RELEASE FORMULATIONS OF DRONEDARONE | LUPIN LIMITED (IN) | 2013-06-06 | — | — | US | disclosed |
| US-20130046103-A1 | PREPARATION OF BENZOFURANS AND USE THEREOF AS SYNTHETIC INTERMEDIATES | MAPI PHARMA LIMITED (IL) | 2013-02-21 | — | — | US | disclosed |
| US-20130012729-A1 | KETOBENZOFURAN DERIVATIVES, METHOD FOR SYNTHESIZING SAME, AND INTERMEDIATES | SANOFI (FR) | 2013-01-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160009678-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY OXIDATION OF A HYDROXYL GROUP | CYP2D6, CYP2B6, POR | ESR1 4284/4885PGR 3657/4885CHRM2 3091/4885 |
| US-20130012729-A1 | KETOBENZOFURAN DERIVATIVES, METHOD FOR SYNTHESIZING SAME, AND INTERMEDIATES | NNMT, DHPS, NDUFC1 | ESR1 4368/4885PGR 4356/4885CHRM2 2347/4885 |
| US-20150037410-A1 | PHARMACEUTICAL COMPOSITIONS OF RANOLAZINE AND DRONEDARONE | RANBP1, SCN5A, CYP2D6 | ESR1 4603/4885PGR 2234/4885CHRM2 1469/4885 |
| US-20150031902-A1 | PROCESS FOR THE PREPARATION OF DRONEDARONE BY OXIDATION OF A SULPHENYL GROUP | CYP3A4, POR, NOX4 | ESR1 4390/4885PGR 4086/4885CHRM2 2823/4885 |
| US-20130142849-A1 | CONTROLLED RELEASE FORMULATIONS OF DRONEDARONE | CYP2D6, CYP3A43, CYP2C9 | ESR1 2415/4885PGR 1506/4885CHRM2 2041/4885 |
| US-20150274688-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY GRIGNARD REACTION | CYP3A4, CYP2C9, CYP4B1 | ESR1 4446/4885PGR 2452/4885CHRM2 3247/4885 |
| US-20130046103-A1 | PREPARATION OF BENZOFURANS AND USE THEREOF AS SYNTHETIC INTERMEDIATES | CYP2F1, CYP4F3, CYP2D6 | ESR1 3895/4885PGR 3820/4885CHRM2 3975/4885 |
| US-20160272606-A1 | PROCESS FOR PREPARATION OF DRONEDARONE BY OXIDATION OF A HYDROXYL GROUP | CYP2D6, CYP2B6, POR | ESR1 4318/4885PGR 3529/4885CHRM2 3022/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.