Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 4/20 | 0.50 |
| ▸ | CNR2 | P34972 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | RAD52 | P43351 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | ERN1 | O75460 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14560451 | 0.74 | HTR6 (0.47) | ALDH1A1KDM4EL3MBTL1TDP1HTR7 | |
| SCHEMBL14560453 | 0.74 | ALDH1A1 (0.48) | ALDH1A1KDM4EHSD17B10HPGDL3MBTL1 | |
| SCHEMBL14560448 | 0.73 | EGFR (0.50) | CNR2ALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL14560443 | 0.73 | EGFR (0.64) | ALDH1A1KDM4EHSD17B10HPGDL3MBTL1 | |
| SCHEMBL14560446 | 0.72 | RAD52 (0.49) | ALDH1A1KDM4EHSD17B10HPGDL3MBTL1 | |
| SCHEMBL14560414 | 0.72 | HTR2A (0.49) | CNR1CNR2ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL14560449 | 0.70 | EGFR (0.47) | ALDH1A1KDM4EHSD17B10HPGDL3MBTL1 | |
| SCHEMBL9691138 | 0.70 | CNR2 (0.57) | CNR1CNR2MEN1KMT2A | |
| SCHEMBL28538811 | 0.69 | CNR2 (0.58) | CNR1CNR2ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL27816681 | 0.69 | LMNA (0.62) | ALDH1A1KDM4EHSD17B10L3MBTL1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7189721-B2 | Bicyclic protein kinase inhibitors | SUGEN INC. (US) | 2007-03-13 | — | — | US | disclosed |
| US-7189721-B2 | Bicyclic protein kinase inhibitors | SUGEN INC. (US) | 2007-03-13 | — | — | US | disclosed |