Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD52 | P43351 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.44 |
| ▸ | ATM | Q13315 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 4/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.41 |
| ▸ | BCL2 | P10415 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14560448 | 0.82 | EGFR (0.50) | ALDH1A1KDM4ETDP1L3MBTL1ATM | |
| SCHEMBL14560443 | 0.82 | EGFR (0.64) | ALDH1A1KDM4ETDP1L3MBTL1ATM | |
| SCHEMBL14560453 | 0.80 | ALDH1A1 (0.48) | ALDH1A1KDM4ETDP1L3MBTL1ATM | |
| SCHEMBL14560449 | 0.78 | EGFR (0.47) | ALDH1A1KDM4ETDP1L3MBTL1ATM | |
| SCHEMBL14560451 | 0.77 | HTR6 (0.47) | ALDH1A1KDM4ETDP1L3MBTL1ATM | |
| SCHEMBL14560411 | 0.74 | ATM (0.43) | ALDH1A1KDM4ETDP1L3MBTL1ATM | |
| SCHEMBL14560439 | 0.72 | CNR1 (0.50) | RAD52ALDH1A1KDM4ESMN1; SMN2TDP1 | |
| SCHEMBL11697896 | 0.71 | POLB (0.63) | ALDH1A1SMN1; SMN2TDP1L3MBTL1MEN1 | |
| SCHEMBL27927319 | 0.71 | RAD52 (0.51) | RAD52ALDH1A1KDM4ESMN1; SMN2TDP1 | |
| SCHEMBL14560403 | 0.71 | RAD52 (0.48) | RAD52ALDH1A1KDM4ETDP1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7189721-B2 | Bicyclic protein kinase inhibitors | SUGEN INC. (US) | 2007-03-13 | — | — | US | disclosed |
| US-7189721-B2 | Bicyclic protein kinase inhibitors | SUGEN INC. (US) | 2007-03-13 | — | — | US | disclosed |