Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.45 |
| ▸ | ATM | Q13315 | 3/20 | 0.45 |
| ▸ | SRC | P12931 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14560443 | 0.89 | EGFR (0.64) | EGFRKDM4ETDP1L3MBTL1ATM | |
| SCHEMBL14560449 | 0.85 | EGFR (0.47) | EGFRKDM4ETDP1L3MBTL1ATM | |
| SCHEMBL14560411 | 0.83 | ATM (0.43) | EGFRKDM4ETDP1L3MBTL1ATM | |
| SCHEMBL14560446 | 0.82 | RAD52 (0.49) | EGFRKDM4ETDP1L3MBTL1ATM | |
| SCHEMBL14560453 | 0.81 | ALDH1A1 (0.48) | EGFRKDM4ETDP1L3MBTL1ATM | |
| SCHEMBL14560451 | 0.78 | HTR6 (0.47) | EGFRKDM4ETDP1L3MBTL1ATM | |
| SCHEMBL8696242 | 0.75 | ALDH1A1 (0.66) | EGFRKDM4EL3MBTL1ATMALDH1A1 | |
| SCHEMBL11605099 | 0.73 | KDM4E (0.63) | KDM4EL3MBTL1ALDH1A1TSHRCNR2 | |
| SCHEMBL14560439 | 0.73 | CNR1 (0.50) | KDM4ETDP1L3MBTL1ATMALDH1A1 | |
| SCHEMBL28826073 | 0.72 | L3MBTL1 (0.46) | EGFRKDM4ETDP1L3MBTL1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7189721-B2 | Bicyclic protein kinase inhibitors | SUGEN INC. (US) | 2007-03-13 | — | — | US | disclosed |
| US-7189721-B2 | Bicyclic protein kinase inhibitors | SUGEN INC. (US) | 2007-03-13 | — | — | US | disclosed |