Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.55 |
| ▸ | ACHE | P22303 | 1/20 | 0.55 |
| ▸ | DRD1 | P21728 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 2/20 | 0.43 |
| ▸ | MC4R | P32245 | 2/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methylpiperazine SCHEMBL27759929 | 0.79 | ADRB1 (0.50) | LMNATSHRALOX12ACHECYP2D6 | |
| Toluene SCHEMBL28974702 | 0.79 | LMNA (0.48) | LMNATSHRALOX12ACHEDRD1 | |
| Toluene SCHEMBL17164584 | 0.79 | LMNA (0.48) | LMNATSHRALOX12ACHEPOLB | |
| Iodobenzene SCHEMBL27797445 | 0.78 | SETD7 (0.42) | DRD1DRD3MC4RCHRM2CHRM4 | |
| Tannin Pyrogallol SCHEMBL29136596 | 0.78 | CHKA (0.58) | TSHRHRH1KCNH2HRH3POLB | |
| N-Methylpiperidine SCHEMBL28303393 | 0.78 | APOBEC3A (0.38) | DRD1DRD3MC4RCHRM2CHRM4 | |
| Toluene SCHEMBL23491537 | 0.78 | ACHE (0.79) | LMNATSHRALOX12ACHEPOLB | |
| Toluene SCHEMBL11529127 | 0.78 | ACHE (0.79) | LMNATSHRALOX12ACHEPOLB | |
| Cyclooctane SCHEMBL16909938 | 0.78 | ACHE (0.79) | LMNATSHRALOX12ACHEPOLB | |
| Toluene SCHEMBL1289937 | 0.78 | ACHE (0.79) | LMNATSHRALOX12ACHEPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011033307-A1 | NILOTINIB DIHYDROCHLORIDE SALT | GENERICS [UK] LIMITED (GB) | 2011-03-24 | — | — | WO | claimed |
| CN-101585739-B | Double-effect water-protecting fertiliser and preparation method thereof | TAIAN ACADEMY OF AGRICULTURAL SCIENCES | 2012-07-04 | — | — | CN | disclosed |
| WO-2011033307-A1 | NILOTINIB DIHYDROCHLORIDE SALT | GENERICS [UK] LIMITED (GB) | 2011-03-24 | — | — | WO | disclosed |
| US-7141586-B2 | Nicotinamide derivatives useful as PDE4 inhibitors | PFIZER INC. (US) | 2006-11-28 | — | — | US | disclosed |
| EP-1651635-A1 | NICOTINAMIDE DERIVATIVES USEFUL AS PDE4 INHIBITORS | Pfizer Limited (GB) | 2006-05-03 | — | — | EP | disclosed |
| US-20050032838-A1 | Nicotinamide derivatives useful as PDE4 inhibitors | PFIZER INC. | 2005-02-10 | — | — | US | disclosed |
| WO-2005009989-A1 | NICOTINAMIDE DERIVATIVES USEFUL AS PDE4 INHIBITORS | PFIZER LIMITED (GB) | 2005-02-03 | — | — | WO | disclosed |
| US-20050020587-A1 | Nicotinamide derivatives useful as PDE4 inhibitors | PFIZER INC | 2005-01-27 | — | — | US | disclosed |
| US-4162269-A | BISULFITE ADDITION USING QUATERNARY AMMONIUM SALT, TERTIARY AMINE SALT, OR MACROCYCLIC POLYETHER AS CATALYST; DECOMPOSITION | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1979-07-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050020587-A1 | Nicotinamide derivatives useful as PDE4 inhibitors | PDE4A, PDE4B, PDE4D | LMNA 312/4885TSHR 3699/4885ALOX12 3209/4885 |
| US-20050032838-A1 | Nicotinamide derivatives useful as PDE4 inhibitors | CBR3, CBR1, PDE9A | LMNA 1560/4885TSHR 765/4885ALOX12 2486/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.