Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CMA1 | P23946 | 2/20 | 0.38 |
| ▸ | CTSG | P08311 | 1/20 | 0.38 |
| ▸ | KMO | O15229 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.33 |
| ▸ | RXRA | P19793 | 2/20 | 0.33 |
| ▸ | RXRB | P28702 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1458449 | 0.93 | KMO (0.39) | CMA1CTSGKMOAKR1C3ALDH1A1 | |
| SCHEMBL1348740 | 0.88 | CMA1 (0.45) | CMA1CTSGKMOAKR1C3ALDH1A1 | |
| SCHEMBL1348608 | 0.81 | MCL1 (0.43) | CMA1CTSGAKR1C3ALDH1A1RAB9A | |
| SCHEMBL1348640 | 0.81 | CMA1 (0.44) | CMA1CTSGKMOAKR1C3ALDH1A1 | |
| SCHEMBL1348509 | 0.74 | PKM (0.37) | CMA1CTSGAKR1C3ALDH1A1RAB9A | |
| SCHEMBL1348981 | 0.74 | NR1H2 (0.42) | ALDH1A1RAB9AKMT2APKM | |
| SCHEMBL15841773 | 0.73 | BCL9 (0.37) | AKR1C3ALDH1A1MAPTRAB9AKMT2A | |
| SCHEMBL1348651 | 0.72 | FFAR1 (0.43) | AKR1C3AKR1C1PKM | |
| SCHEMBL15841692 | 0.71 | CHRNB2 (0.38) | CMA1CTSGAKR1C3ALDH1A1RAB9A | |
| SCHEMBL1347258 | 0.71 | CTSG (0.46) | CMA1CTSGALDH1A1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2288594-A1 | IMIDAZOLIDINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2011-03-02 | — | — | EP | disclosed |
| WO-2009150109-A1 | IMIDAZOLIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2009-12-17 | — | — | WO | disclosed |