Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Orotic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | GPR84 | Q9NQS5 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Orotic Acid SCHEMBL6754685 | 0.86 | LMNA (0.66) | LMNAALDH1A1CYP1A2GPR84MEN1 | |
| Orotic Acid SCHEMBL672753 | 0.85 | LMNA (0.57) | LMNAALDH1A1CYP1A2GPR84MEN1 | |
| Orotic Acid SCHEMBL422601 | 0.80 | LMNA (0.63) | LMNAALDH1A1CYP1A2GPR84MEN1 | |
| Orotic Acid SCHEMBL9726375 | 0.80 | LMNA (0.63) | LMNAALDH1A1CYP1A2GPR84MEN1 | |
| Orotic Acid SCHEMBL896843 | 0.80 | LMNA (0.63) | LMNAALDH1A1CYP1A2GPR84MEN1 | |
| Orotic Acid SCHEMBL23859826 | 0.80 | LMNA (0.63) | LMNAALDH1A1CYP1A2GPR84MEN1 | |
| Orotic Acid SCHEMBL1854526 | 0.80 | LMNA (0.63) | LMNAALDH1A1CYP1A2GPR84MEN1 | |
| Orotic Acid SCHEMBL5148012 | 0.80 | LMNA (0.63) | LMNAALDH1A1CYP1A2GPR84MEN1 | |
| Orotic Acid SCHEMBL20518755 | 0.80 | LMNA (0.63) | LMNAALDH1A1CYP1A2GPR84MEN1 | |
| Orotic Acid SCHEMBL366202 | 0.80 | LMNA (0.63) | LMNAALDH1A1CYP1A2GPR84MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3212191-B1 | TREATMENT FOR DEPRESSION AND DEPRESSIVE DISORDERS | MEDLAB IP PTY LTD (AU) | 2022-10-05 | — | — | EP | claimed |
| US-11135181-B2 | Treatment for depression and depressive disorders | MEDLAB IP PTY LTD (AU) | 2021-10-05 | — | — | US | claimed |
| US-20170312232-A1 | TREATMENT FOR DEPRESSION AND DEPRESSIVE DISORDERS | MEDLAB IP PTY LTD (AU) | 2017-11-02 | — | — | US | claimed |
| EP-3212191-A1 | TREATMENT FOR DEPRESSION AND DEPRESSIVE DISORDERS | Medlab IP Pty Ltd. (AU) | 2017-09-06 | — | — | EP | claimed |
| WO-2016065419-A1 | TREATMENT FOR DEPRESSION AND DEPRESSIVE DISORDERS | MEDLAB IP PTY LTD (AU) | 2016-05-06 | — | — | WO | claimed |
| US-20150335688-A1 | PROBIOTIC COMBINATIONS AND USES THEREOF | MEDLAB IP PTY LTD (AU) | 2015-11-26 | — | — | US | claimed |
| WO-2010005123-A1 | COMPOSITION FOR ENHANCING BIOSYNTHESIS OF HYALURONIC ACID OR GLYCOSAMINOGLYCAN COMPRISING OROTIC ACID, A SALT THEREOF, OR A DERIVATIVE THEREOF | MAZENCE INC. (KR) | 2010-01-14 | — | — | WO | claimed |
| EP-1537896-B1 | Compound mixtures based on sulphur containing amino acids, antioxidants, phospholipids and vitamins for the preparation of a medicament for treating L-diabetes and/or associated diseases. | LIEBEL FRANZ-PETER DR (DE) | 2008-04-02 | — | — | EP | claimed |
| US-4061741-A | OROTIC ACID OR SALTS | FIRMA SERVOMED ARZEI GMBH & CO. PHARMA KG (DT) | 1977-12-06 | — | — | US | claimed |
| EP-3212191-B1 | TREATMENT FOR DEPRESSION AND DEPRESSIVE DISORDERS | MEDLAB IP PTY LTD (AU) | 2022-10-05 | — | — | EP | disclosed |
| US-11135181-B2 | Treatment for depression and depressive disorders | MEDLAB IP PTY LTD (AU) | 2021-10-05 | — | — | US | disclosed |
| WO-2020218492-A1 | COMPOSITION | 興和株式会社 | 2020-10-29 | — | — | WO | disclosed |
| WO-2019189714-A1 | COMPOSITION | 興和株式会社 | 2019-10-03 | — | — | WO | disclosed |
| EP-2963023-B1 | PROCESS FOR PREPARING 5-AMINO-1, 2, 3-TRIAZOLE OROTATE DERIVATIVES | TACTICAL THERAPEUTICS INC (US) | 2018-04-18 | — | — | EP | disclosed |
| CN-101478981-A | Pharmaceutical agent for prevention of fatigue and/or recovery from fatigue | KOWA CO (JP) | 2009-07-08 | — | — | CN | disclosed |
| WO-2008120070-A2 | 2(HYDROXYETHYL)TRIMETHYLAMMONIUM THIOCTATE (CHOLINE THIOCTATE) DISPLAYING HEPATOPROTECTIVE, HYPOAMMONIEMIC AND DETOXIC ACTION, A METHOD FOR ITS PRODUCTION AND A PHARMACEUTICAL COMPOSITION BASED THEREON | AKTSIONERNE TOVARYSTVO VIDKRYTOGO TYPU «GALYCHFARM» (UA) | 2008-10-09 | — | — | WO | disclosed |
| CN-1935227-A | Medicine composition for improving sleep | SSP CO LTD (JP) | 2007-03-28 | — | — | CN | disclosed |
| US-20040247686-A1 | Pharmaceutical compositions comprising epinastine for the treatment of skin diseases | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2004-12-09 | — | — | US | disclosed |
| WO-2004087167-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING EPINASTINE FOR THE TREATMENT OF SKIN DISEASES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2004-10-14 | — | — | WO | disclosed |
| US-4061741-A | OROTIC ACID OR SALTS | FIRMA SERVOMED ARZEI GMBH & CO. PHARMA KG (DT) | 1977-12-06 | — | — | US | disclosed |