Known targets — ChEMBL curated mechanism
GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHMGCRMMP1MMP13MMP7MMP8PTGS1PTGS2ileSpolrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Orotic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | YTHDF3 | Q7Z739 | 1/20 | 0.36 |
| ▸ | YTHDF1 | Q9BYJ9 | 1/20 | 0.36 |
| ▸ | YTHDF2 | Q9Y5A9 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Orotic Acid SCHEMBL377013 | 0.98 | LMNA (0.61) | LMNAALDH1A1CYP1A2GPR84CA1 | |
| Orotic Acid SCHEMBL366202 | 0.96 | LMNA (0.63) | LMNAALDH1A1CYP1A2GPR84CA1 | |
| Orotic Acid SCHEMBL1854526 | 0.96 | LMNA (0.63) | LMNAALDH1A1CYP1A2GPR84CA1 | |
| Orotic Acid SCHEMBL896843 | 0.96 | LMNA (0.63) | LMNAALDH1A1CYP1A2GPR84CA1 | |
| Orotic Acid SCHEMBL11903508 | 0.96 | ALDH1A1 (0.63) | LMNAALDH1A1CYP1A2GPR84CA1 | |
| Orotic Acid SCHEMBL23859826 | 0.96 | LMNA (0.63) | LMNAALDH1A1CYP1A2GPR84CA1 | |
| Orotic Acid SCHEMBL5148012 | 0.96 | LMNA (0.63) | LMNAALDH1A1CYP1A2GPR84CA1 | |
| Orotic Acid SCHEMBL161884 | 0.96 | LMNA (0.63) | LMNAALDH1A1CYP1A2GPR84CA1 | |
| Orotic Acid SCHEMBL20518755 | 0.96 | LMNA (0.63) | LMNAALDH1A1CYP1A2GPR84CA1 | |
| Orotic Acid SCHEMBL1005000 | 0.96 | LMNA (0.63) | LMNAALDH1A1CYP1A2GPR84CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 347 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025059346-A1 | FUNGAL CURD COMPOSITIONS | THE FYNDER GROUP, INC. (US) | 2025-03-20 | — | — | WO | claimed |
| EP-4319788-A1 | REGULATION OF CELLS AND ORGANISMS | Tets, Victor (US) | 2024-02-14 | — | — | EP | claimed |
| US-20230277486-A1 | COMPOSITIONS FOR THE TREATMENT OF NON-ARTICULAR CARTILAGE-ASSOCIATED BONE CONDITIONS | JOHNSON LANNY LEO (US) | 2023-09-07 | — | — | US | claimed |
| CN-112515033-B | Collagen active peptide for balancing hormone in vivo and production process thereof | 北美生命科学(上海)有限公司 | 2022-10-25 | — | — | CN | claimed |
| WO-2022214966-A1 | REGULATION OF CELLS AND ORGANISMS | TETS VICTOR (US) | 2022-10-13 | — | — | WO | claimed |
| EP-3212191-B1 | TREATMENT FOR DEPRESSION AND DEPRESSIVE DISORDERS | MEDLAB IP PTY LTD (AU) | 2022-10-05 | — | — | EP | claimed |
| US-11147761-B2 | Topical supplement composition and method of use | AKMENKALNS NICOLE (US) | 2021-10-19 | — | — | US | claimed |
| US-11135181-B2 | Treatment for depression and depressive disorders | MEDLAB IP PTY LTD (AU) | 2021-10-05 | — | — | US | claimed |
| US-20200230197-A1 | MULTI-NUTRIENT COMPOSITION | EXERKINE CORP (CA) | 2020-07-23 | — | — | US | claimed |
| US-20200069573-A1 | Topical Supplement Composition and Method of Use | AKMENKALNS NICOLE (US) | 2020-03-05 | — | — | US | claimed |
| EP-1971351-A2 | MINERAL-HERBAL PREPARATION CONSISTING OF ZEOLITE AND ASTRAGALUS MEMBRANACEUS ROOT EXTRACT TO TREAT ALLERGIES | Basic, Robert (HR) | 2008-09-24 | — | — | EP | claimed |
| WO-2007074349-A2 | MINERAL-HERBAL PREPARATION CONSISTING OF ZEOLITE AND ASTRAGALUS MEMBRANACEUS ROOT EXTRACT TO TREAT ALLERGIES | BASIC ROBERT (HR) | 2007-07-05 | — | — | WO | claimed |
| CN-1314361-C | Joint healthy beverage or food and preparation thereof | LI ANHU (CN) | 2007-05-09 | — | — | CN | claimed |
| US-20040198695-A1 | Joint-protecting beverages and/or foods and their preparations | LI ANHU (CN) | 2004-10-07 | — | — | US | claimed |
| CN-1439313-A | Joint healthy beverage or food and preparation thereof | LI ANHU (CN) | 2003-09-03 | — | — | CN | claimed |
| US-20020193323-A1 | Compositions and methods for promoting a healthy cardiovascular system and enhancing blood flow | YEGOROVA INNA (US) | 2002-12-19 | — | — | US | claimed |
| US-20020176900-A1 | Compositions and methods for promoting a healthy cardiovascular system and enhancing blood flow | YEGOROVA INNA (US) | 2002-11-28 | — | — | US | claimed |
| US-4738856-A | Beverage and method for making a beverage for the nutritional supplementation of calcium in humans | NUTRITION TECHNOLOGIES, INC. (US) | 1988-04-19 | — | — | US | claimed |
| EP-0246177-A2 | A beverage and method for making a beverage for the nutritional supplementation of calcium in humans | Clark, George H. (US) | 1987-11-19 | — | — | EP | claimed |
| EP-0208362-A1 | Dietary supplements containing iron and enterically coated calcium | THE PROCTER & GAMBLE COMPANY (US) | 1987-01-14 | — | — | EP | claimed |