Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Orotic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | YTHDF3 | Q7Z739 | 1/20 | 0.36 |
| ▸ | YTHDF1 | Q9BYJ9 | 1/20 | 0.36 |
| ▸ | YTHDF2 | Q9Y5A9 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Orotic Acid SCHEMBL1005000 | 0.96 | LMNA (0.63) | LMNAALDH1A1CYP1A2GPR84CA1 | |
| Orotic Acid SCHEMBL422601 | 0.96 | LMNA (0.63) | LMNAALDH1A1CYP1A2GPR84CA1 | |
| Orotic Acid SCHEMBL1854526 | 0.96 | LMNA (0.63) | LMNAALDH1A1CYP1A2GPR84CA1 | |
| Orotic Acid SCHEMBL896843 | 0.96 | LMNA (0.63) | LMNAALDH1A1CYP1A2GPR84CA1 | |
| Orotic Acid SCHEMBL161884 | 0.96 | LMNA (0.63) | LMNAALDH1A1CYP1A2GPR84CA1 | |
| Orotic Acid SCHEMBL23859826 | 0.96 | LMNA (0.63) | LMNAALDH1A1CYP1A2GPR84CA1 | |
| Orotic Acid SCHEMBL11903508 | 0.96 | ALDH1A1 (0.63) | LMNAALDH1A1CYP1A2GPR84CA1 | |
| Orotic Acid SCHEMBL5148012 | 0.96 | LMNA (0.63) | LMNAALDH1A1CYP1A2GPR84CA1 | |
| Orotic Acid SCHEMBL20518755 | 0.96 | LMNA (0.63) | LMNAALDH1A1CYP1A2GPR84CA1 | |
| Orotic Acid SCHEMBL9726375 | 0.96 | LMNA (0.63) | LMNAALDH1A1CYP1A2GPR84CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 157 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250367169-A1 | FORMULATIONS FOR PERSONALIZED METHODS OF TREATMENT | FAETH THERAPEUTICS INC (US) | 2025-12-04 | — | — | US | claimed |
| EP-4633638-A1 | TREATMENT OF PSYCHOLOGICAL FACTORS AFFECTING OTHER MEDICAL CONDITIONS (PFAOMC) | Luminous Mind Inc. (US) | 2025-10-22 | — | — | EP | claimed |
| US-12220402-B2 | Formulations for personalized methods of treatment | FAETH THERAPEUTICS, INC. (US) | 2025-02-11 | — | — | US | claimed |
| WO-2024130044-A1 | TREATMENT OF PSYCHOLOGICAL FACTORS AFFECTING OTHER MEDICAL CONDITIONS (PFAOMC) | LUMINOUS MIND INC. (US) | 2024-06-20 | — | — | WO | claimed |
| EP-4319788-A1 | REGULATION OF CELLS AND ORGANISMS | Tets, Victor (US) | 2024-02-14 | — | — | EP | claimed |
| CN-116075238-A | Formulations for personalized therapeutic methods | 菲思治疗公司 | 2023-05-05 | — | — | CN | claimed |
| EP-4161501-A1 | FORMULATIONS FOR PERSONALIZED METHODS OF TREATMENT | Faeth Therapeutics, Inc. (US) | 2023-04-12 | — | — | EP | claimed |
| WO-2022214966-A1 | REGULATION OF CELLS AND ORGANISMS | TETS VICTOR (US) | 2022-10-13 | — | — | WO | claimed |
| EP-3212191-B1 | TREATMENT FOR DEPRESSION AND DEPRESSIVE DISORDERS | MEDLAB IP PTY LTD (AU) | 2022-10-05 | — | — | EP | claimed |
| US-20220152093-A1 | OPTIMIZED NUTRIENT SALT COMPOSITION | VADAKKEMURI JOLLY MATHEW (IN) | 2022-05-19 | — | — | US | claimed |
| US-20170312232-A1 | TREATMENT FOR DEPRESSION AND DEPRESSIVE DISORDERS | MEDLAB IP PTY LTD (AU) | 2017-11-02 | — | — | US | claimed |
| EP-3212191-A1 | TREATMENT FOR DEPRESSION AND DEPRESSIVE DISORDERS | Medlab IP Pty Ltd. (AU) | 2017-09-06 | — | — | EP | claimed |
| WO-2016065419-A1 | TREATMENT FOR DEPRESSION AND DEPRESSIVE DISORDERS | MEDLAB IP PTY LTD (AU) | 2016-05-06 | — | — | WO | claimed |
| US-20150335688-A1 | PROBIOTIC COMBINATIONS AND USES THEREOF | MEDLAB IP PTY LTD (AU) | 2015-11-26 | — | — | US | claimed |
| US-20120020945-A1 | Food Supplement and Method for Enhancing Athletic Performance | NUTRITIONAL ERGOGENIC SYSTEMS (US) | 2012-01-26 | — | — | US | claimed |
| US-8067537-B2 | Composition and method for treatment of stomatitis | KYOWA HAKKO BIO CO., LTD. (JP) | 2011-11-29 | — | — | US | claimed |
| US-20090285912-A1 | Food Supplement and Method for Enhancing Athletic Performance | NUTRITIONAL ERGOGENIC SYSTEMS | 2009-11-19 | — | — | US | claimed |
| US-4738856-A | Beverage and method for making a beverage for the nutritional supplementation of calcium in humans | NUTRITION TECHNOLOGIES, INC. (US) | 1988-04-19 | — | — | US | claimed |
| EP-0246177-A2 | A beverage and method for making a beverage for the nutritional supplementation of calcium in humans | Clark, George H. (US) | 1987-11-19 | — | — | EP | claimed |
| EP-0202106-A2 | A beverage and method of making a beverage for the replacement of body fluids and electrolytes | Clark, George H. (US) | 1986-11-20 | — | — | EP | claimed |