Orotic Acid

Orotic Acid

SCHEMBL896843

O=C([O-])c1cc(=O)[nH]c(=O)[nH]1.O=C([O-])c1cc(=O)[nH]c(=O)[nH]1.[Cu+2]

nearest known ligand 0.63

Full drug profile on Sugi Atlas →

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.63
ALDH1A1 P00352 1/20 0.63
CYP1A2 P05177 1/20 0.55
GPR84 Q9NQS5 4/20 0.44
CA1 P00915 1/20 0.41
CYP2C19 P33261 1/20 0.39
MEN1 O00255 2/20 0.38
KMT2A Q03164 2/20 0.38
YTHDF3 Q7Z739 1/20 0.36
YTHDF1 Q9BYJ9 1/20 0.36
YTHDF2 Q9Y5A9 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
TSHR P16473 2/20 0.34
HSD17B10 Q99714 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
NPC1 O15118 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Orotic Acid SCHEMBL159382 0.96 LMNA (0.63) LMNAALDH1A1CYP1A2GPR84CA1
Orotic Acid SCHEMBL366202 0.96 LMNA (0.63) LMNAALDH1A1CYP1A2GPR84CA1
Orotic Acid SCHEMBL1854526 0.96 LMNA (0.63) LMNAALDH1A1CYP1A2GPR84CA1
Orotic Acid SCHEMBL11903508 0.96 ALDH1A1 (0.63) LMNAALDH1A1CYP1A2GPR84CA1
Orotic Acid SCHEMBL161884 0.96 LMNA (0.63) LMNAALDH1A1CYP1A2GPR84CA1
Orotic Acid SCHEMBL23859826 0.96 LMNA (0.63) LMNAALDH1A1CYP1A2GPR84CA1
Orotic Acid SCHEMBL5148012 0.96 LMNA (0.63) LMNAALDH1A1CYP1A2GPR84CA1
Orotic Acid SCHEMBL422601 0.96 LMNA (0.63) LMNAALDH1A1CYP1A2GPR84CA1
Orotic Acid SCHEMBL20518755 0.96 LMNA (0.63) LMNAALDH1A1CYP1A2GPR84CA1
Orotic Acid SCHEMBL9726375 0.96 LMNA (0.63) LMNAALDH1A1CYP1A2GPR84CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 50 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025029611-A1 THERAPIES FOR DISEASES OF COPPER METABOLISM THE CURATORS OF THE UNIVERSITY OF MISSOURI (US) 2025-02-06 WO claimed
EP-3212191-B1 TREATMENT FOR DEPRESSION AND DEPRESSIVE DISORDERS MEDLAB IP PTY LTD (AU) 2022-10-05 EP claimed
US-11135181-B2 Treatment for depression and depressive disorders MEDLAB IP PTY LTD (AU) 2021-10-05 US claimed
US-10905744-B2 Pharmaceutical formulations for the oral delivery of peptide drugs CYPRUMED GMBH (AT) 2021-02-02 US claimed
EP-3204045-B1 PHARMACEUTICAL FORMULATIONS FOR THE ORAL DELIVERY OF PEPTIDE OR PROTEIN DRUGS CYPRUMED GMBH (AT) 2018-12-05 EP claimed
US-20180280481-A1 PHARMACEUTICAL FORMULATIONS FOR THE ORAL DELIVERY OF PEPTIDE DRUGS CYPRUMED GMBH (AT) 2018-10-04 US claimed
US-20170312232-A1 TREATMENT FOR DEPRESSION AND DEPRESSIVE DISORDERS MEDLAB IP PTY LTD (AU) 2017-11-02 US claimed
US-20170304195-A1 PHARMACEUTICAL FORMULATIONS FOR THE ORAL DELIVERY OF PEPTIDE OR PROTEIN DRUGS CYPRUMED GMBH (AT) 2017-10-26 US claimed
EP-3212191-A1 TREATMENT FOR DEPRESSION AND DEPRESSIVE DISORDERS Medlab IP Pty Ltd. (AU) 2017-09-06 EP claimed
WO-2016065419-A1 TREATMENT FOR DEPRESSION AND DEPRESSIVE DISORDERS MEDLAB IP PTY LTD (AU) 2016-05-06 WO claimed
US-20150335688-A1 PROBIOTIC COMBINATIONS AND USES THEREOF MEDLAB IP PTY LTD (AU) 2015-11-26 US claimed
WO-2012096655-A1 COMPOSITIONS FOR TREATING CHRONIC VIRAL INFECTIONS ANG SAM POON (US) 2012-07-19 WO claimed
US-20120082720-A1 Compositions For Treating Chronic Viral Infections ANG SAM POON (US) 2012-04-05 US claimed
US-7939109-B1 Method of treating neoplastic disease in a human or animal patient CARTER JOHN 2011-05-10 US claimed
US-7758899-B2 Pharmaceutical compositions and their use in the treatment of neoplastic disease CARTER JOHN 2010-07-20 US claimed
US-20070225367-A1 Composition for beneficially influencing Alzheimer's disease and/or for Alzheimer's prophylaxis CLARIANT INTERNATIONAL LTD 2007-09-27 US claimed
EP-1220678-B1 PHARMACEUTICAL COMPOSITIONS CONTAINING COPPER, SALICYLIC ACID AND VITAMIN C CARTER JOHN (GB) 2007-03-07 EP claimed
US-20050123623-A1 Pharmaceutical compositions and their use in the treatment of neoplastic disease CARTER JOHN (GB) 2005-06-09 US claimed
WO-2025029611-A1 THERAPIES FOR DISEASES OF COPPER METABOLISM THE CURATORS OF THE UNIVERSITY OF MISSOURI (US) 2025-02-06 WO disclosed
WO-2001024803-A2 PHARMACEUTICAL COMPOSITIONS CONTAINING COPPER, SALICYLIC ACID AND VITAMINES C CARTER JOHN (GB) 2001-04-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170304195-A1 PHARMACEUTICAL FORMULATIONS FOR THE ORAL DELIVERY OF PEPTIDE OR PROTEIN DRUGS SLC30A5, SLC30A6, SON LMNA 4870/4885ALDH1A1 3933/4885CYP1A2 3809/4885
US-20180280481-A1 PHARMACEUTICAL FORMULATIONS FOR THE ORAL DELIVERY OF PEPTIDE DRUGS SLC30A5, SLC39A11, SLC30A6 LMNA 4860/4885ALDH1A1 3473/4885CYP1A2 3593/4885
US-20120082720-A1 Compositions For Treating Chronic Viral Infections HAVCR2, FABP1, LIPC LMNA 1999/4885ALDH1A1 1924/4885CYP1A2 829/4885
US-10905744-B2 Pharmaceutical formulations for the oral delivery of peptide drugs SLC30A5, SLC39A11, SLC30A6 LMNA 4860/4885ALDH1A1 3473/4885CYP1A2 3593/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.