Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Orotic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | GPR84 | Q9NQS5 | 5/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | GPR35 | Q9HC97 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Orotic Acid SCHEMBL1461341 | 0.86 | LMNA (0.46) | LMNAALDH1A1CYP1A2GPR84TSHR | |
| Orotic Acid SCHEMBL20865 | 0.81 | ALDH1A1 (1.00) | LMNAALDH1A1CYP1A2CYP2C19GPR84 | |
| Orotic Acid SCHEMBL29394966 | 0.81 | ALDH1A1 (1.00) | LMNAALDH1A1CYP1A2CYP2C19GPR84 | |
| Orotic Acid SCHEMBL431534 | 0.81 | ALDH1A1 (1.00) | LMNAALDH1A1CYP1A2CYP2C19GPR84 | |
| Orotic Acid SCHEMBL18894201 | 0.79 | ALDH1A1 (0.88) | LMNAALDH1A1CYP1A2CYP2C19GPR84 | |
| Orotic Acid SCHEMBL23859825 | 0.79 | ALDH1A1 (0.95) | LMNAALDH1A1CYP1A2CYP2C19GPR84 | |
| Orotic Acid SCHEMBL422602 | 0.79 | ALDH1A1 (0.95) | LMNAALDH1A1CYP1A2CYP2C19GPR84 | |
| Orotic Acid SCHEMBL896844 | 0.79 | ALDH1A1 (0.95) | LMNAALDH1A1CYP1A2CYP2C19GPR84 | |
| Orotic Acid SCHEMBL1005001 | 0.79 | ALDH1A1 (0.95) | LMNAALDH1A1CYP1A2CYP2C19GPR84 | |
| Orotic Acid SCHEMBL231368 | 0.79 | ALDH1A1 (0.95) | LMNAALDH1A1CYP1A2CYP2C19GPR84 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004087167-A2 | PHARMACEUTICAL COMPOSITIONS COMPRISING EPINASTINE FOR THE TREATMENT OF SKIN DISEASES | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2004-10-14 | — | — | WO | disclosed |